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Tauroursodeoxycholate (UR 906) 是一种天然的高度亲水性的三级胆汁酸。Tauroursodeoxycholate 可用于原发性胆汁性肝硬化 (PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症的研究。
Tauroursodeoxycholate (UR 906) 是一种天然的高度亲水性的三级胆汁酸。Tauroursodeoxycholate 可用于原发性胆汁性肝硬化 (PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症的研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 mg | ¥ 475 | 现货 | |
100 mg | ¥ 618 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 248 | 现货 |
产品描述 | Tauroursodeoxycholate (UR 906) is a naturally occurring, highly hydrophilic, tertiary bile acid. Tauroursodeoxycholate is used in studies of primary biliary cirrhosis (PBC), insulin resistance, amyloidosis, cystic fibrosis, cholestasis and amyotrophic lateral sclerosis. |
体外活性 | 方法:过表达 WDR45 突变的 HeLa 细胞用 Tauroursodeoxycholate (200 µM) 处理 24 h,使用 Western Blot 检测靶点蛋白表达水平。 结果:使用 Tauroursodeoxycholate 抑制 ER 应激显著降低了表达突变 WDR45 的细胞中 p38 和 LAMP2A 的磷酸化以及 mCherry KFERQ 的点状形成。[1] 方法:未分化神经干细胞 NSCs 用 Tauroursodeoxycholate (100 µM) 处理 24 h,通过 BrdU 用 Flow cytometry 检测细胞增殖。 结果:Tauroursodeoxycholate 孵育后 BrdU 掺入显著增加。Tauroursodeoxycholate 调节细胞增殖。[2] |
体内活性 | 方法:为检测对糖尿病的作用,将 Tauroursodeoxycholate (300 mg/kg) 腹腔注射给 STZ 诱导糖尿病的 C57BL/6 小鼠,每天一次,持续二十四天。 结果:治疗 15 天后,与 STZ 组相比,STZ+Tauroursodeoxycholate 小鼠的血糖降低了 43%。这种减少可能是由于胰岛素血症的增加。[3] |
别名 | 牛磺熊去氧胆酸, Taurolite, Tauroursodeoxycholic Acid, UR 906, Ursodeoxycholyltaurine, TUDCA |
分子量 | 499.7 |
分子式 | C26H45NO6S |
CAS No. | 14605-22-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
溶解度信息 | 5% DMSO+95% Saline: 4.5 mg/mL (9.01 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO: 6.25 mg/mL (12.51 mM), Sonication is recommended. | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
5% DMSO+95% Saline/DMSO
DMSO
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