Taltobulin trifluoroacetate

Name: Taltobulin trifluoroacetate
Brand: TargetMol
SKU: T13073
Price: 333 USD
Availability: InStock
Rating: 4.5 (1 reviews)

还可以

产品编号 T13073Cas号 228266-41-9

别名 SPA-110 trifluoroacetate, HTI-286 trifluoroacetate

Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Taltobulin trifluoroacetate

还可以

产品编号 T13073 别名 SPA-110 trifluoroacetate, HTI-286 trifluoroacetateCas号 228266-41-9

Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

规格	价格	库存	数量
2 mg	¥ 1,750	5日内发货

大包装 & 定制

加入购物车

该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。但由于客观因素，研发中会存在小概率合成不成功的情况，还请理解，如您有任何问题，欢迎咨询，我们将竭诚为您服务。

实验操作小课堂

联系我们获取更多批次信息

资源下载

产品操作手册

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述	Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
体外活性	The growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines) inhibited by Taltobulin (HTI-286; 0.2-7.3 nM; 3 days)(with an average IC50 of 2.5±2.1 nM and a median value of 1.7 nM).
体内活性	In athymic nu/nu female mice, Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) . Taltobulin (HTI-286; 3 mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu female mice with Lox melanoma xenografts and KB-3-1 epidermoid xenograft model, respectively.
别名	SPA-110 trifluoroacetate, HTI-286 trifluoroacetate

化学信息

分子量	587.681
分子式	C₂₉H₄₄F₃N₃O₆
CAS No.	228266-41-9
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 39 mg/mL (66.36 mM)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7016 mL	8.5080 mL	17.0160 mL	85.0802 mL
5 mM	0.3403 mL	1.7016 mL	3.4032 mL	17.0160 mL
10 mM	0.1702 mL	0.8508 mL	1.7016 mL	8.5080 mL
20 mM	0.0851 mL	0.4254 mL	0.8508 mL	4.2540 mL
50 mM	0.0340 mL	0.1702 mL	0.3403 mL	1.7016 mL