Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In the myocardial cell, white blood cell, vascular smooth muscle cell, and endothelial cell, Polydatin can inhibit ICAM-1 expression, elevate Ca2+, weaken white blood cell-endothelial cell adhesion, and activate KATP channels.

Polydatin 通过改善微循环和抑制血小板聚集保护大脑细胞免受缺血损害。此外，Polydatin 在内皮细胞中抑制由脂多糖刺激引起的ICAM-1表达，同时减少白细胞与内皮细胞之间的粘附[1]。

Polydatin能显著提高SOD活性和心率，减轻心肌病理损伤，降低MDA含量，轻微提升动脉压和GSH-Px活性，缩短QRS、QT和ST间期，并降低FFA含量。Polydatin与维生素C联用可显著提升动脉压和心率，缩短QRS间期，轻微减短ST和QT间期，显著减轻心肌病理损伤，提高GSH-Px、T-SOD、Na+ K+ -ATPase和Ca2+ Mg2+ -ATPase的活性，提升磷酸肌酸（PCr）和三磷酸腺苷（ATP）含量，轻微增加二磷酸腺苷（ADP）和总腺嘌呤核苷酸（TAN）含量及PCr/ATP，显著降低MDA和FFA含量。

The effect of polydatin on mMEC viability is evaluated with an MTT assay. mMECs are incubated in the presence or absence of various concentrations of polydatin (25, 50 and 100 μg/mL) and DEX (100 μg/mL) for 24 h. Next, 20 μL of MTT (5 mg/mL) is added to each well and incubated for 4 h. After the supernatants are removed and the formazan is dis?solved with 150 μL of DMSO in each well, the optical density (OD) value is measured at 570 nm on a microplate reader[3].