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Pemigatinib (INCB054828) 是一种口服具有活力的,选择性的 FGFR 抑制剂,能够作用于 FGFR1 (IC50:0.4 nM),FGFR2 (IC50:0.5 nM),FGFR3 (IC50:1.2 nM),FGFR4 (IC50:30 nM),有用于胆管癌的潜力。
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Pemigatinib (INCB054828) 是一种口服具有活力的,选择性的 FGFR 抑制剂,能够作用于 FGFR1 (IC50:0.4 nM),FGFR2 (IC50:0.5 nM),FGFR3 (IC50:1.2 nM),FGFR4 (IC50:30 nM),有用于胆管癌的潜力。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 413 | 现货 | |
5 mg | ¥ 993 | 现货 | |
10 mg | ¥ 1,570 | 现货 | |
25 mg | ¥ 2,730 | 现货 | |
50 mg | ¥ 3,960 | 现货 | |
100 mg | ¥ 5,650 | 现货 | |
200 mg | ¥ 7,680 | 现货 |
产品描述 | Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR(IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively). |
靶点活性 | FGFR2:0.5 nM, FGFR1:0.4 nM, FGFR3:1.2 nM, FGFR4:30 nM |
体外活性 | In cells expressing FGFR2-CLIP1 fusion are sensitive to Pemigatinib (INCB054828; IC50 value of 10.16 nM)[3]. |
别名 | INCB054828 |
分子量 | 487.5 |
分子式 | C24H27F2N5O4 |
CAS No. | 1513857-77-6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | DMSO: 4.88 mg/mL (10 mM), Sonication is recommended. 10% DMSO+90% Saline: 0.1 mg/mL (0.21 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. |
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