XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metabolic disorders.

小鼠接受含60%高脂饮食，其中包含15%的d-xylose、10%或15%的XYLOBIOSE，作为总蔗糖含量的一部分，持续十周。XYLOBIOSE补充显著降低了体重、脂肪和肝脏重量、空腹血糖以及血脂水平。同时，XYLOBIOSE补充还改善了瘦素和脂肪细胞因子水平，并且在网膜脂肪和肝脏中调低了脂肪生成和脂肪细胞生成基因的表达。此外，XYLOBIOSE补充还降低了网膜脂肪中的促炎细胞因子、脂肪酸摄取、脂解作用和β-氧化相关基因的表达水平[1]。XYLOBIOSE通过调节miR-122a/33a轴，在db/db小鼠中展示了抗糖尿病、降脂和抗炎的效果[2]。

The mice were randomized into five groups: (a) a control group (Ctrl, n = 10) which received a diet of modified American Institute of Nutrition (AIN)-93G (17% of the calories are from fat); (b) a high fat diet (HFD)-induced obesity control group (HF, n = 13) which received a HFD comprised of 60% fat; (c) a xylose 15% group (Xylo 15) which received a HFD with 15% of the total sucrose replaced with d-xylose (n = 13); (d) an XYLOBIOSE 10% group (XYLOBIOSE 10, n = 13) which received a HFD with 10% of the total sucrose replaced by XYLOBIOSE; and (e) an XYLOBIOSE 15% group (XYLOBIOSE 15, n = 12) which received a HFD with 15% of the total sucrose replaced by XYLOBIOSE. Commercially available D-xylose was included as a positive control and was administered at a dose comparable to XYLOBIOSE. The mice were maintained on these diets according to their group for ten weeks prior to sacrifice. Body weight and food intake were measured twice a week.