Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ro24-7429 是一种有效的口服活性 HIV-1 反式激活蛋白 Tat 拮抗剂和一种矮小相关转录因子 1 的抑制剂。Ro24-7429 具有抗 HIV、抗纤维化和抗炎作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 849 | 现货 | ||
5 mg | ¥ 1,980 | 现货 | ||
10 mg | ¥ 3,130 | 现货 | ||
25 mg | ¥ 5,170 | 现货 | ||
50 mg | ¥ 7,320 | 现货 | ||
100 mg | ¥ 9,870 | 现货 | ||
500 mg | ¥ 19,700 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,150 | 现货 |
产品描述 | Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects. |
体外活性 | Ro24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours[1]. Ro 24-7429 (1-25 μM) induces apoptosis and inhibits antigen-induced lymphocyte proliferation. Ro 24-7429 (0.1 μM, 1 μM, 5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner[2]. |
体内活性 | Ro24-7429 (17.5-70 mg/kg; i.p.) curbs expression of fibrosis markers in injured mouse lungs. Ro24-7429 robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis mouse model[1]. |
别名 | Ro 24-7429, Ro-24-7429, Ro 247429 |
分子量 | 272.73 |
分子式 | C14H13ClN4 |
CAS No. | 139339-45-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (220.00 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.6666 mL | 18.3332 mL | 36.6663 mL | 91.6658 mL |
5 mM | 0.7333 mL | 3.6666 mL | 7.3333 mL | 18.3332 mL | |
10 mM | 0.3667 mL | 1.8333 mL | 3.6666 mL | 9.1666 mL | |
20 mM | 0.1833 mL | 0.9167 mL | 1.8333 mL | 4.5833 mL | |
50 mM | 0.0733 mL | 0.3667 mL | 0.7333 mL | 1.8333 mL | |
100 mM | 0.0367 mL | 0.1833 mL | 0.3667 mL | 0.9167 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ro24-7429 139339-45-0 Microbiology/Virology Proteases/Proteasome HIV Protease Tat anti-inflammatory antifibrotic inhibit Ro247429 RUNX1 Inhibitor Ro 24-7429 Ro-24-7429 Apoptosis Human immunodeficiency virus HIV-1 anti-HIV Ro24 7429 Ro 247429 HIV inhibitor