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Lodoxamide

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产品编号 T4566Cas号 53882-12-5
别名 洛草氨酸, Lodoxamidum

Lodoxamide (Lodoxamidum) 是一种抗过敏药物,作为肥大细胞稳定剂,对治疗哮喘和过敏性结膜炎有效。

Lodoxamide
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Lodoxamide

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纯度: 99.81%
产品编号 T4566 别名 洛草氨酸, LodoxamidumCas号 53882-12-5

Lodoxamide (Lodoxamidum) 是一种抗过敏药物,作为肥大细胞稳定剂,对治疗哮喘和过敏性结膜炎有效。

规格价格库存数量
1 mg¥ 218现货
5 mg¥ 488现货
10 mg¥ 747现货
25 mg¥ 1,220现货
50 mg¥ 1,730现货
100 mg¥ 2,490现货
200 mg¥ 3,690现货
500 mg¥ 5,980现货
1 mL x 10 mM (in DMSO)¥ 488现货
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产品介绍

生物活性
产品描述
Lodoxamide (Lodoxamidum) is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis.
体外活性
Lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45Ca influx with associated histamine release in purified rat peritoneal mast cells [1]. The chemotactic response of eosinophils to fMLP as well as to IL-5 is significant and dose-dependent inhibited by Lodoxamide. Lodoxamide is also able to strongly inhibit the release of eosinophil peroxidase after IgA-dependent activation and, to a lesser extent, the release of eosinophil cationic protein and eosinophil-derived neurotoxin [2].
体内活性
Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anaesthetized rhesus monkeys [1]. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation decreased microvascular permeability, and increased compliance [3].
别名洛草氨酸, Lodoxamidum
化学信息
分子量311.63
分子式C11H6ClN3O6
CAS No.53882-12-5
SmilesOC(=O)C(=O)Nc1cc(cc(NC(=O)C(O)=O)c1Cl)C#N
密度1.78g/cm3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 55 mg/mL (176.49 mM)
溶液配制表
1mg5mg10mg50mg
1 mM3.2089 mL16.0447 mL32.0893 mL160.4467 mL
5 mM0.6418 mL3.2089 mL6.4179 mL32.0893 mL
10 mM0.3209 mL1.6045 mL3.2089 mL16.0447 mL
20 mM0.1604 mL0.8022 mL1.6045 mL8.0223 mL
50 mM0.0642 mL0.3209 mL0.6418 mL3.2089 mL
100 mM0.0321 mL0.1604 mL0.3209 mL1.6045 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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