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Lodoxamide (Lodoxamidum) 是一种抗过敏药物,作为肥大细胞稳定剂,对治疗哮喘和过敏性结膜炎有效。
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Lodoxamide (Lodoxamidum) 是一种抗过敏药物,作为肥大细胞稳定剂,对治疗哮喘和过敏性结膜炎有效。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 218 | 现货 | |
5 mg | ¥ 488 | 现货 | |
10 mg | ¥ 747 | 现货 | |
25 mg | ¥ 1,220 | 现货 | |
50 mg | ¥ 1,730 | 现货 | |
100 mg | ¥ 2,490 | 现货 | |
200 mg | ¥ 3,690 | 现货 | |
500 mg | ¥ 5,980 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 488 | 现货 |
产品描述 | Lodoxamide (Lodoxamidum) is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis. |
体外活性 | Lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45Ca influx with associated histamine release in purified rat peritoneal mast cells [1]. The chemotactic response of eosinophils to fMLP as well as to IL-5 is significant and dose-dependent inhibited by Lodoxamide. Lodoxamide is also able to strongly inhibit the release of eosinophil peroxidase after IgA-dependent activation and, to a lesser extent, the release of eosinophil cationic protein and eosinophil-derived neurotoxin [2]. |
体内活性 | Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anaesthetized rhesus monkeys [1]. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation decreased microvascular permeability, and increased compliance [3]. |
别名 | 洛草氨酸, Lodoxamidum |
分子量 | 311.63 |
分子式 | C11H6ClN3O6 |
CAS No. | 53882-12-5 |
Smiles | OC(=O)C(=O)Nc1cc(cc(NC(=O)C(O)=O)c1Cl)C#N |
密度 | 1.78g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/mL (176.49 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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