产品描述	Ampyrone (4-Aminoantipyrine) is a reagent for glucose determination in the presence of peroxidase and phenol.
体外活性	The level of glutathione(GSH) in single erythrocytes is impacted slightly at low AAP(4-aminoantipyrine) concentrations probably due to the protection of glutathione reductase. When AAP concentration further increases, AAP has a significant influence on GSH[2].
体内活性	4-aminoantipyrine (4-AA) is not genotoxic and mutagenic in vivo, it can interfere with DNA damaging agents biological activities and may reduce the effectiveness of DNA damage-based chemotherapy[3].
细胞实验	Erythrocytes in PBS are incubated for 2 h at ambient temperature (without mixing) with AAP in concentrations from 1 × 10−6 mol/L to 1 × 10−3 mol/L. Sample of erythrocytes without AAP is used as control. After the exposure of AAP, erythrocytes are washed with borate buffer (pH 9.0) 2 times by centrifuging and determined for GSH. (Only for Reference)
别名	Minoazophene, Aminoantipyrin, NSC 60242, 4-氨基安替比林, 4-Aminoantipyrine, Solnapyrin-A

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

Ethanol: 40 mg/mL (196.81 mM)

H2O: 37 mg/mL (182.1 mM)

溶液配制表

H2O/Ethanol

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLddH2O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多