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ACBI1 是一种基于PROTAC 技术的 BAF ATPase 亚基SMARCA2和SMARCA4降解剂,也是 PBAF 成员PBRM1的降解剂。它由一个 bromodomain 配体、linker 和 E3 泛素连接酶von Hippel-Lindau 构成,能诱导抗增殖作用和凋亡。
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ACBI1 是一种基于PROTAC 技术的 BAF ATPase 亚基SMARCA2和SMARCA4降解剂,也是 PBAF 成员PBRM1的降解剂。它由一个 bromodomain 配体、linker 和 E3 泛素连接酶von Hippel-Lindau 构成,能诱导抗增殖作用和凋亡。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 991 | 现货 | |
5 mg | ¥ 2,430 | 现货 | |
10 mg | ¥ 3,880 | 现货 | |
25 mg | ¥ 6,230 | 现货 | |
50 mg | ¥ 8,560 | 现货 | |
100 mg | ¥ 11,500 | 现货 | |
500 mg | ¥ 22,900 | 现货 |
产品描述 | ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis. |
靶点活性 | SMARCA4:11 nM (DC50), SMARCA2:6 nM (DC50), PBRM1:32 nM (DC50) |
分子量 | 936.1 |
分子式 | C49H58FN9O7S |
CAS No. | 2375564-55-7 |
Smiles | NC1=C(C=C(N=N1)C2=C(O)C=CC=C2)N3CCN(CC4=CC=C(OCCOC5=C(CNC(=O)[C@H]6N(C([C@@H](NC(=O)C7(F)CC7)C(C)(C)C)=O)C[C@H](O)C6)C=CC(=C5)C8=C(C)N=CS8)C=C4)CC3 |
密度 | 1.41 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 100 mg/mL (106.83 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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