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Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) 是一种特异性的粘着斑激酶抑制剂,能够降低其自身磷酸化活性,抑制癌细胞的活力,阻断肿瘤生长。
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Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) 是一种特异性的粘着斑激酶抑制剂,能够降低其自身磷酸化活性,抑制癌细胞的活力,阻断肿瘤生长。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 197 | 现货 | |
10 mg | ¥ 327 | 现货 | |
25 mg | ¥ 512 | 现货 | |
50 mg | ¥ 690 | 现货 | |
100 mg | ¥ 1,270 | 现货 | |
200 mg | ¥ 1,880 | 现货 | |
500 mg | ¥ 3,230 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 229 | 现货 |
产品描述 | Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth. |
体外活性 | Y15 inhibited viability in ?thyroid cancer cell lines in a dose-dependent manner[1]. |
细胞实验 | Apoptosis assay was done with PE Annexin V Apoptosis Detection Kit (BD) to identify apoptotic nuclei.?One hundred millimeter plates were seeded with TPC1, K1, BCPAP and TT cells at a concentration of 1 × 10^6 cells in normal growth media.?After overnight incubation, plates were treated with one of several doses of Y15 or left untreated.?After another 24 h of incubation, cells were collected with trypsin, and following centrifugation, were washed with 1× PBS.?Again, cells were centrifuged, PBS was removed and cells were resuspended in binding buffer and filtered through BD mesh tubes.?Annexin V and 7-AAD were added to the solution, vortexed and incubated for 15 minutes in the dark.?Binding buffer was added and the cells were analyzed by flow cytometry within 1 hour. |
别名 | FAK Inhibitor 14, 1,2,4,5-苯四胺四盐酸盐, 1,2,4,5-Benzenetetramine tetrahydrochlor |
分子量 | 284.01 |
分子式 | C6H14Cl4N4 |
CAS No. | 4506-66-5 |
Smiles | Cl.Cl.Cl.Cl.Nc1cc(N)c(N)cc1N |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | H2O: 59 mg/mL (207.74 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||||||||||||
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