Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) 是一种有效的、可口服的、具有抗肿瘤活性的选择性 ATR 抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 478 | 现货 | ||
2 mg | ¥ 695 | 现货 | ||
5 mg | ¥ 1,320 | 现货 | ||
10 mg | ¥ 1,990 | 现货 | ||
25 mg | ¥ 3,990 | 现货 | ||
50 mg | ¥ 5,680 | 现货 | ||
100 mg | ¥ 7,930 | 现货 | ||
500 mg | ¥ 15,900 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,420 | 现货 |
产品描述 | Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activity. |
靶点活性 | ATR:7 nM |
体外活性 | Elimusertib hydrochloride potently inhibits the proliferation of a broad spectrum of human tumor cell lines (median IC50: 78 nM). BAY-1895344 potently suppresses NSC-32065-induced H2AX phosphorylation (IC50: 36 nM) [1]. |
体内活性 | In a variety of xenograft models of ovarian and colorectal cancer, Elimusertib hydrochloride shows potent anti-tumor efficacy in monotherapy and causes complete tumor remission in mantle cell lymphoma models [2]. |
别名 | BAY-1895344 hydrochloride |
分子量 | 411.89 |
分子式 | C20H22ClN7O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (121.39 mM), Sonication and heating are recommended.
H2O: 48 mg/mL (116.53 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 2.4278 mL | 12.1392 mL | 24.2783 mL | 60.6958 mL |
5 mM | 0.4856 mL | 2.4278 mL | 4.8557 mL | 12.1392 mL | |
10 mM | 0.2428 mL | 1.2139 mL | 2.4278 mL | 6.0696 mL | |
20 mM | 0.1214 mL | 0.607 mL | 1.2139 mL | 3.0348 mL | |
50 mM | 0.0486 mL | 0.2428 mL | 0.4856 mL | 1.2139 mL | |
100 mM | 0.0243 mL | 0.1214 mL | 0.2428 mL | 0.607 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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