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Elenbecestat (E2609) 是一种高效、有口服活性的,能透过 CNS 的 BACE-1抑制剂,它有用于阿尔茨海默病 (AD) 的研究潜力。
Elenbecestat (E2609) 是一种高效、有口服活性的,能透过 CNS 的 BACE-1抑制剂,它有用于阿尔茨海默病 (AD) 的研究潜力。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 567 | 现货 | |
5 mg | ¥ 1,580 | 现货 | |
10 mg | ¥ 2,680 | 现货 | |
25 mg | ¥ 4,580 | 现货 | |
50 mg | ¥ 6,530 | 现货 | |
100 mg | ¥ 8,890 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 1,710 | 现货 |
产品描述 | Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease. |
体外活性 | E2609 has been shown to reduce Ab production in the plasma, brain, and cerebrospinal fluid (CSF) of rodents.E2609 is a potent BACE1 inhibitor with an IC50 of ~7 nmol/L in cell-based assay. |
体内活性 | E2609 (0.3-30 mg/kg; p.o.) potently inhibits Ab1-40 and Ab1-42 production in the plasma and CSF of non-human primates.E2609 displays the plasma half-life of 12-16 hours after once daily dosing. |
别名 | E2609 |
分子量 | 437.44 |
分子式 | C19H18F3N5O2S |
CAS No. | 1388651-30-6 |
Smiles | [H][C@]12CSC(N)=N[C@]1(CO[C@@H]2C)c1cc(NC(=O)c2cnc(cn2)C(F)F)ccc1F |
密度 | 1.61 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 250 mg/mL (571.51 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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