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SCH 57790 是一种新型且具有选择性的毒蕈碱 M(2) 受体拮抗剂,可释放乙酰胆碱并增强实验动物的认知能力,可用于治疗阿尔茨海默病。
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SCH 57790 是一种新型且具有选择性的毒蕈碱 M(2) 受体拮抗剂,可释放乙酰胆碱并增强实验动物的认知能力,可用于治疗阿尔茨海默病。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,780 | 现货 | |
5 mg | ¥ 4,480 | 现货 | |
10 mg | ¥ 6,380 | 现货 | |
25 mg | ¥ 9,620 | 现货 | |
50 mg | ¥ 12,900 | 现货 | |
100 mg | ¥ 17,500 | 现货 |
产品描述 | SCH 57790 is a novel and selective muscarinic M(2) receptor antagonist that releases acetylcholine and enhances cognition in experimental animals for the treatment of Alzheimer's disease. |
体内活性 | SCH 57790 (0.1-10 mg/kg; p.o.) produced dose-related increases in acetylcholine release from rat hippocampus, cortex, and striatum. SCH 57790 (0.003-1.0 mg/kg) increased retention times in young rat passive avoidance responding when given either before or after training. Also, SCH 57790 reversed scopolamine-induced deficits in mice in a passive avoidance task. In a working memory operant task in squirrel monkeys, administration of SCH 57790 (0.01-0.03 mg/kg) improved performance under a schedule of fixed-ratio discrimination with titrating delay. The effects observed with SCH 57790 in behavioral studies were qualitatively similar to the effects produced by the clinically used cholinesterase inhibitor donepezil, suggesting that blockade of muscarinic M(2) receptors is a viable approach to enhancing cognitive performance.[2] |
别名 | SCH-57790, SCH57790 |
分子量 | 437.6 |
分子式 | C25H31N3O2S |
CAS No. | 221660-80-6 |
Smiles | C(C#N)(N1CCN(CC1)C2CCCCC2)C3=CC=C(S(=O)C4=CC=C(OC)C=C4)C=C3 |
密度 | 1.26 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
溶解度信息 | DMSO: 20 mg/mL (45.7 mM), Sonication is recommended. | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
DMSO
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