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Rebamipide (OPC12759) 是一种粘膜保护剂,可诱导COX-2表达,增加PGE2水平,并以 COX-2 依赖性方式增强胃粘膜防御。
Rebamipide (OPC12759) 是一种粘膜保护剂,可诱导COX-2表达,增加PGE2水平,并以 COX-2 依赖性方式增强胃粘膜防御。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
500 mg | ¥ 334 | 现货 | |
1 g | ¥ 415 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 142 | 现货 |
产品描述 | Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense. |
别名 | 瑞巴派特, Proamipide, OPC12759 |
分子量 | 370.79 |
分子式 | C19H15ClN2O4 |
CAS No. | 90098-04-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 6.88 mg/mL (18.54 mM), Sonication is recommended. | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
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