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NMDA (N-Methyl-D-aspartic acid) 是一种氨基酸,作为 D-异构体,是谷氨酸受体的 NMDA 受体亚型的定义激动剂。
NMDA (N-Methyl-D-aspartic acid) 是一种氨基酸,作为 D-异构体,是谷氨酸受体的 NMDA 受体亚型的定义激动剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 233 | 现货 | |
50 mg | ¥ 388 | 现货 | |
100 mg | ¥ 624 | 现货 | |
500 mg | ¥ 1,548 | 期货 |
产品描述 | N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA (N-Methyl-D-aspartic acid) receptor subtype of glutamate receptors. |
体外活性 | NMDA是一种兴奋性氨基酸神经递质,仅与NMDA受体结合,不影响其他谷氨酸受体(例如AMPA和kainate受体)。NMDA特异性结合于NMDA受体的NR2亚单位,随后促进非特异性阳离子通道的打开,允许Ca2+和Na+进入细胞内,以及K+离开细胞。NMDA受体的激活能够产生兴奋性突触后电位(EPSP),并触发细胞内Ca2+含量的增加,进一步参与多种信号传递途径。NMDA受体在广泛的生理(例如长期增强和神经可塑性)及病理过程(例如兴奋毒性和癫痫)中发挥关键作用。[1] |
体内活性 | 微注射NMDA(0.2 nM)对MF、IF、IL和EL分别具有显著影响,降低了交尾频次和插入频次,并缩短了插入和射精潜伏期。分别在交配测试30分钟内,NMDA和AP-5显著地促进和抑制了射精行为。向PVN双侧微注射NMDA显著增加了基线LSNA,LSNA峰值增量在NMDA注入PVN后5分钟内出现[3]。 |
激酶实验 | Adrenal membranous homogenate suspensions are incubated with 10 nM [3H]Glu in 500/zl 50 mM Tris-acetate buffer (pH 7.4) at 2°C or 30°C in the presence and absence of various compounds. Incubation is terminated by the addition of 3 mL ice-cold buffer and subsequent filtration through a Whatman GF/B glass filter under a constant vacuum of 15 mm Hg. After washing the filter 4 times with 3 mL icecold buffer, the radioactivity trapped on the filter is measured by a liquid scintillation spectrometer using 5 mL modified Triton-toluene scintillant at a counting efficiency of 40-42%. The radioactivity found in the presence of 1 mM non-radioactive Glu is subtracted from each experimental value to obtain the specific binding of [3H]GIu in accordance with the y-aminobutyric acid (GABA) receptor binding assay system. The kinetic parameters of [3H]GIu binding, Kd and Bma x, are calculated by Scatchard analysis of the specific binding using a personal computer with a programme for non-linear regression analysis developed in our own laboratory. |
别名 | N-甲基-D-天冬氨酸, N-Methyl-D-aspartic acid |
分子量 | 147.13 |
分子式 | C5H9NO4 |
CAS No. | 6384-92-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | H2O: 30 mg/mL (203.9 mM), Sonication is recommended. DMSO: 15 mg/mL (101.95 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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