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VER49009 (CCT0129397) 是一种有效的 HSP90 抑制剂(IC50 =25 nM,Kd=78 nM)。
VER49009 (CCT0129397) 是一种有效的 HSP90 抑制剂(IC50 =25 nM,Kd=78 nM)。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 543 | 现货 | |
2 mg | ¥ 789 | 现货 | |
5 mg | ¥ 1,580 | 现货 | |
10 mg | ¥ 2,690 | 现货 | |
25 mg | ¥ 4,490 | 现货 | |
50 mg | ¥ 6,420 | 现货 | |
100 mg | ¥ 8,790 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 1,380 | 现货 |
产品描述 | VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM). |
靶点活性 | HSP90:25 nM |
体外活性 | 在人卵巢肿瘤模型中,腹腔注射VER-49009(4 mg/kg)能够诱导HSP90与ERBB2的解离.在无胸腺的小鼠中,静脉注射VER-49009(20 mg/kg )能够发挥有效作用. |
体内活性 | VER-49009能够诱导HSP72和HSP27与与其结合蛋白解离,导致细胞周期停滞。在重组的酵母Hsp90蛋白中(IC50=167 nM),VER-49009能够抑制內源性ATP酶活性。在肝纤维化的治疗中,VER-49009能够诱导肝细胞CFSC在G2期停滞积累,抑制细胞生长。 |
激酶实验 | Fluorescence Polarization Assay: Binding of HSP90 inhibitors to human full-length recombinant HSP90β is determined by a competitive binding fluorescence polarization assay, using a fluorescent pyrazole resorcinol probe. |
细胞实验 | Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method. (Only for Reference) |
别名 | VER-49009, VER 49009, CCT0129397 |
分子量 | 387.82 |
分子式 | C19H18ClN3O4 |
CAS No. | 940289-57-6 |
Smiles | c1(c(cc(c(c1)c1c(c([nH]n1)C(=O)NCC)c1ccc(cc1)OC)O)O)Cl |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 71 mg/mL (183.1 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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