Pridopidine

产品编号 T7352Cas号 346688-38-8

别名 ACR16|||ASP2314|||FR310826|||4-[3-(甲磺酰基)苯基]-1-丙基哌啶

Pridopidine (FR310826) 是多巴胺稳定剂，是一种低亲和力的多巴胺 D2 受体拮抗剂。它高亲和力作用于 sigma 1受体，Ki=70-80 nM，比其对 D2R 的亲和力高约 100 倍。

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Pridopidine

产品编号 T7352别名 ACR16, ASP2314, FR310826, 4-[3-(甲磺酰基)苯基]-1-丙基哌啶Cas号 346688-38-8

规格	价格	库存
1 mg	¥ 119	现货
5 mg	¥ 317	现货
10 mg	¥ 497	现货
25 mg	¥ 942	现货
50 mg	¥ 1,420	现货
100 mg	¥ 2,130	现货
1 mL x 10 mM (in DMSO)	¥ 269	现货

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产品介绍

生物活性

产品描述	Pridopidine (FR310826), a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model.
靶点活性	σ1 receptor:70-80 nM (Ki)
体内活性	Pridopidine的作用通过S1R介导，导致YAC128 MSNs中ER Ca2+释放、ER Ca2+水平和spine SOC入口的正常化。这是pridopidine作用机制的一个新发现，凸显S1R作为HD治疗的潜在靶点。长期使用pridopidine治疗可能通过上调调节钙的纹状体蛋白，包括calbindin和homer1a，进一步为HD中pridopidine的长期有益效果贡献。
动物实验	Sprague Dawley rats (n = 6) were treated daily by oral gavage with pridopidine (60 mg/kg) over 10 days. Six control Sprague Dawley rats were vehicle-treated. On the 10th day, 90 min following the last drug administration, brains were removed and RNA was isolated from the striatum of each rat and was analyzed using Affymetrix Rat 230_2 arrays. The gene expression data from 12 striatum samples was RMA normalized with affy package v1.42.3 in R v3.1.2. Probesets were annotated . The limma package v3.18.13 in R v3.1.3 was used to test if relevant calcium-related genes were differentially expressed between the two groups of biological replicates and multiple hypothesis testing was corrected for using the Bonferroni correction. Limma employs an empirical Bayes method to moderate standard error . When a gene had multiple probesets, the probeset with the highest absolute value of fold change was reported[1].
别名	ACR16, ASP2314, FR310826, 4-[3-(甲磺酰基)苯基]-1-丙基哌啶

化学信息

分子量	281.41
分子式	C₁₅H₂₃NO₂S
CAS No.	346688-38-8

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 45 mg/mL (159.91 mM)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5535 mL	17.7677 mL	35.5353 mL	177.6767 mL
5 mM	0.7107 mL	3.5535 mL	7.1071 mL	35.5353 mL
10 mM	0.3554 mL	1.7768 mL	3.5535 mL	17.7677 mL
20 mM	0.1777 mL	0.8884 mL	1.7768 mL	8.8838 mL
50 mM	0.0711 mL	0.3554 mL	0.7107 mL	3.5535 mL
100 mM	0.0355 mL	0.1777 mL	0.3554 mL	1.7768 mL