M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.

M8 B作为TRPM8拮抗剂，能够降低体温。在幼鼠实验中，M8 B降低了体温，并延长了首次发热性抽搐的潜伏期，表现出显著的保护作用。此外，M8 B在PTZ引起的抽搐中显示出明显的抗惊厥效果，但在电休克引发的抽搐中则没有这种效果。M8 B在发热性和PTZ引起的抽搐中均展现了抗惊厥效果，并具有明显的降温作用，对发热性和PTZ引起的抽搐具有显著的保护效果。

Eight day old male Wistar rat pups were used for induction of febrile seizure.?M8 B and diazepam were injected intraperitoneally.?The rat pups were then transferred to a heated plexiglas chamber and the latency to the first febrile seizure was measured.?In addition, different groups of mice were pretreated with M8 B and received a convulsant dose of pentylenetetrazol (PTZ).?Latencies to stages 2 and 4 and duration of stage 5 seizure episodes were measured.The effect of M8 B on electroshock induced seizures was also investigated and hindlimb extension time was measured[1].