529
62
7
48
14
Cat. No. | Product Name | ||
---|---|---|---|
L2690 | 疼痛相关化合物库 | 2739 compounds | |
2739种疼痛相关化合物的独特集合,可用于高通量筛选和高内涵筛选 | |||
L4020 | NO PAINS 化合物库 | 9384 compounds | |
TargetMol NO PAINS 化合物库包含 9384 个剔除了PAINS 的小分子活性化合物,可用于新药研发,信号通路研究,老药新用等研究。 | |||
L7200 | 钙通道分子库 | 140 compounds | |
140 种钙通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L4710 | 非甾体类抗炎化合物库 | 530 compounds | |
530 种非甾体类的抗炎相关化合物,可用于高通量和高内涵筛选; | |||
L2300 | 离子通道库 | 931 compounds | |
931 种与离子通道相关的生物活性小分子化合物的特有集合,用于离子通道相关的疾病和药物研究,可用于高通量筛选和高内涵筛选; | |||
L6710 | 中药抗炎分子库 | 1246 compounds | |
1246 种具有抗炎活性或靶向炎症相关靶点的中药单体集合,是药物开发、药理研究的有效工具; | |||
L7400 | 钠通道分子库 | 118 compounds | |
118 种钠通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9530 |
W 36017
|
Others | Others |
W36017 是利多卡因的一种杂质,其阻滞神经活性的pKa为 7.4。 | |||
T7688 |
4-Nonylphenylboronic acid
|
FAAH | Metabolism; Neuroscience |
4-Nonylphenylboronic acid 是 FAAH 的抑制剂。 | |||
T8538 |
ML382
|
MRGPR | GPCR/G Protein |
ML382 是选择性的 Mas 相关 G 蛋白偶联受体 X1MRGPRX1 (MrgX1)正向调节剂,其EC50=190 nM。 | |||
T7526 |
JNJ-17203212
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
JNJ-17203212 是一种竞争性 TRPV1选择性拮抗剂。它被开发用于疼痛处理的研究。 | |||
T9683 |
VX-150
|
Sodium Channel | Membrane transporter/Ion channel |
VX-150 是一种口服有效的,高选择性的 NaV1.8抑制剂。VX-150 在各种疼痛适应症中有研究的价值。 | |||
T8410 |
ASP7663
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
ASP7663 是口服有效的TRPA1选择性激动剂。ASP7663具有抗便秘和抗腹痛的功效。 | |||
T5460 |
Mofezolac
莫苯唑酸,莫非佐酸 |
COX | Immunology/Inflammation; Neuroscience |
Mofezolac 是一种非甾体类抗炎药,可缓解疼痛并具有抗炎活性,抑制 COX-1和COX-2的IC50为 1.44 和 447 nM。 | |||
T5513 |
RO-3
|
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
RO3 是一种能透过大脑的P2X3和P2X2/3拮抗剂,口服有活性。它对人同型多聚体 P2X3和异型多聚体 P2X2/3受体的 pIC50分别为 5.9 和 7.0。 | |||
T60003 |
AC1-IN-1
|
Adenylyl cyclase | Neuroscience |
AC1-IN-1 是 1 型腺苷酸环化酶的选择性抑制剂(AC1,IC50 = 0.54 µM)。 | |||
T4542 |
Clonixin
Clonixic acid,氯尼辛 |
Others | Others |
Clonixin (Clonixic acid) 是一种非甾体抗炎药,具有口服活性。 | |||
T21543 |
AP 18
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
AP-18 是选择性的 TRPA1 抑制剂。AP-18 可以抑制 50 μM 肉桂醛诱导的 TRPA1 激活,在小鼠和人中的 IC50 分别为 4.5 μM 和 3.1 μM。AP-18 可以逆转 CFA 诱导的小鼠机械性痛觉过敏。AP-18 可以浓度依赖的方式减弱 30 μM AITC 诱导的 Yo-Pro 摄取(IC50= 10.3 μM)。 | |||
T8975 |
PSB-SB-487
|
Cannabinoid Receptor | GPCR/G Protein |
PSB-SB-487 是 GPR55 的拮抗剂。 | |||
T7061 |
Duloxetine
|
Serotonin Transporter | Neuroscience |
Duloxetine 是一种 5 羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂,Ki=4.6 nM,可作用于广泛性焦虑症的研究。 | |||
T7502L |
PF 05089771
PF-05089771,PF05089771 |
Sodium Channel | Membrane transporter/Ion channel |
PF 05089771是具有口服有效的、选择性的 Nav1.7丙烯酰胺抑制剂。PF-05089771在疼痛和糖尿病神经性疾病的研究中具有价值。 | |||
T0463 |
Loxoprofen
Loxoprofene,洛索洛芬,Loxoprofeno,Koloxo |
COX | Immunology/Inflammation; Neuroscience |
Loxoprofen (Koloxo) 是一种非甾体类抗炎药,具有解热作用,可用于缓解疼痛的研究。它是非选择性COX 抑制剂,对 COX-1 和 COX-2 的IC50分别为 6.5 和 13.5 μM。 | |||
T9461 |
AZ194
|
Sodium Channel | Membrane transporter/Ion channel |
CRMP2-Ubc9-NaV1.7 inhibitor 194 是一流的CRMP2-Ubc9相互作用抑制剂及NaV1.7抑制剂 (IC50=1.2 μM),口服有活性,具有抗伤害作用。AZ194 阻断 CRMP2 的 SUMOylation 以选择性地减少表面表达 NaV1.7 的量。 | |||
T22360 |
MDR-652
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
MDR-652是瞬时受体电位香草酸亚型 1 的选择性激动剂,对 hTRPV1 和 rTRPV1 的Ki 分别为 11.4 和 23.8 nM,EC50分别为 5.05 和 93 nM。MDR-652在缓解疼痛方面有研究的价值。 | |||
T9400 |
KCNQ2/3 activator-1
|
Others; Potassium Channel | Membrane transporter/Ion channel; Others |
KCNQ2/3 activator-1 是Kv7.2/Kv7.3(KCNQ2/3) 钾通道激活剂,详细信息来自专利 WO2021113757A1的化合物 A。 | |||
T0159 |
Pranoprofen
普拉洛芬,Pyranoprofen |
Apoptosis; COX; PGE Synthase; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Pranoprofen (Pyranoprofen) 可抑制COX1/2酶,阻断花生四烯酸转化为二十烷醇,减少前列腺素的合成。它是一种用于眼科的非甾体抗炎试剂。 | |||
T16014 |
Mavatrep
JNJ-39439335 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Mavatrep (JNJ-39439335) 是一种特异性的 TRPV1 拮抗剂,Ki 为 6.5 nM,可用于炎症性疼痛的研究。 | |||
T40045 |
Sivopixant
S-600918,Sivopixant |
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
Sivopixant (S-600918) 是P2X3受体选择性拮抗剂 (P2X3IC50=4.2 nM; P2X2/3IC50=1100 nM)。Sivopixant 可用于缓解疼痛的研究。 | |||
T7882 |
Indomethacin farnesil
吲哚美辛法呢酯,Infree |
Others; COX; Autophagy | Autophagy; Immunology/Inflammation; Neuroscience; Others |
Indomethacin farnesil (Infree) 是具有口服活性的 Indomethacin 前药,可通过干扰溶酶体的正常功能来破坏自噬流,有抗炎和抗风湿作用。它是一种可透过血脑屏障的,非选择性的 COX1和 COX2抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50值分别为 18 nM 和 26 nM。 | |||
T6043 |
PF-3845
|
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
PF3845 是一种有效的、选择性的和不可逆的脂肪酸酰胺水解酶(FAAH)抑制剂,Ki 为 230 nM。它是将 FAAH 的丝氨酸亲核试剂氨基甲酸酯化的共价抑制剂,可以减少疼痛感、炎症和焦虑或抑郁。 | |||
T4298 |
JNJ-47965567
JNJ-479655 |
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
JNJ-47965567 (JNJ-479655) 是中枢通透性、高亲和力、选择性的P2X7拮抗剂,可用于探讨中枢 P2X7 在中枢神经系统病理生理模型中的作用。它对人和大鼠 P2X7 作用的pKi 值分别为 7.9 和 8.7。 | |||
T22086 |
HA 155
Autotaxin Inhibitor IV |
PDE | Metabolism |
HA 155 (Autotaxin Inhibitor IV) 是一种基于硼酸的化合物,通过选择性结合其催化苏氨酸来抑制 ATX,IC50 为 5.7 nM。 | |||
T16483 |
PF-05105679
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
PF-05105679 是一种特异性 TRPM8 拮抗剂 (IC50 = 103 nM)。 PF-05105679 可用于冷相关疼痛的研究。 | |||
T9833 |
Opiranserin hydrochloride
|
P2X Receptor; GlyT; 5-HT Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Opiranserin hydrochloride 是甘氨酸转运蛋白 2 型 (GlyT2) 和 5-羟色胺受体 2A (5HT2A) 的双重拮抗剂,IC50 分别为 0.86 和 1.3 μM。它显示对 rP2X3 的拮抗活性 (IC50=0.87 μM)。它正在开发为用于治疗术后疼痛的注射剂。 | |||
TQ0002 |
A-317491
ABT 202 |
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
A-317491 (ABT 202) 是选择性和非核苷酸的 P2X3和 P2X2/3受体的拮抗剂,通过阻断 P2X3和 P2X2/3受体介导的钙通量减轻炎性和神经性疼痛。它对其他 P2 受体和神经递质受体,离子通道以及酶具有高度选择性,IC50大于10 μM。 | |||
T14844 |
BX430
|
P2X Receptor; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Neuroscience |
BX430 是一种有效的选择性非竞争性变构人 P2X4 受体通道拮抗剂,IC50 为 0.54 μM。它具有物种特异性,可用于治疗慢性疼痛和心血管疾病。 | |||
T21976 |
ONO-8130
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
ONO-8130 是前列腺素 EP1 受体选择性拮抗剂,口服有活力,能够阻断 L6 脊髓中ERK 的磷酸化。它可缓解环磷酰胺致膀胱炎小鼠的膀胱疼痛,可用于研究间质性膀胱炎。 | |||
T7502 |
PF 05089771 tosylate
|
Sodium Channel | Membrane transporter/Ion channel |
PF 05089771 tosylate 是口服有效的、选择性的Nav1.7丙烯酰胺抑制剂。PF 05089771 tosylate 具有用于疼痛和糖尿病神经性疾病的研究。 | |||
T11147 |
EC5026
BPN-19186 |
Epoxide Hydrolase | Metabolism |
EC5026 (BPN-19186) 是首创的,非阿片类的,可溶性环氧水解酶 (sEH) 抑制剂,它可有效缓解发炎性和神经性疼痛。 | |||
T7774 |
A2793
2-[(5-氯-8-喹啉基)氧基]乙酸乙酯 |
Potassium Channel | Membrane transporter/Ion channel |
A2793 是 TWIK 相关酸敏感 K+通道 1(TASK-1)/TRESK 的双重抑制剂,对 mTRESK 的 IC50为 6.8 μM。它对 TRESK 选择性更好, 对 TREK-1 和 TALK-1 相对弱一些。 | |||
T9330 |
MIPS521
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
MIPS521 ({2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone) 是腺苷受体 (A1AR) 的正向变构调节剂,通过调节大鼠脊髓中内源性腺苷水平的升高,在体内表现出减轻疼痛的作用。 | |||
T8834 |
EST64454 hydrochloride
EST64454 |
Sigma receptor | GPCR/G Protein |
EST64454 hydrochloride (EST64454) 是一种可口服的选择性sigma-1受体拮抗剂,Ki 为 22 nM。它有用于疼痛的研究潜力。 | |||
T7748 |
Dermorphin TFA
皮啡肽三氟乙酸盐 |
Others; Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience; Others |
Dermorphin TFA 是在两栖类皮肤中发现的天然七肽,是 μ-阿片受体激动剂,可用于抑制神经痛。 | |||
T7416 |
WS-12
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
WS-12 是有效的TRPM8激动剂,EC50为 39 nM。 | |||
T2067 |
NS11394
NS 11394 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
NS11394 是可口服GABAA 的阳性变构调节剂 (PAM),Ki 值为 0.5 nM。它对GABAA 的选择性依次为 α5、α3、α2 和α1 受体,具有抗炎和抗焦虑活性。 | |||
T8711 |
PF-05186462
PF-05150122 |
Sodium Channel | Membrane transporter/Ion channel |
PF-05186462 (PF-05150122)是选择性的人Nav1.7电压依赖性钠通道抑制剂,IC50为 21 nM,与其他钠通道 (Nav 1.1、1.2、1.3、1.4、1.5、1.6 和 1.8) 相比,它对 Nav1.7显示出显著的选择性。PF-05186462在急性或慢性疼痛中具有研究价值。 | |||
T22733 |
DL-AP5
DL-2-氨基-5-膦酰基缬草酸 |
NMDAR | Neuroscience |
DL-AP5 是选择性 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂的外消旋形式,具有抗惊厥作用。 | |||
T23469 |
TQS
4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide |
AChR | Neuroscience |
TQS (4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) 是 α7 烟碱乙酰胆碱受体正变构调节剂,可用于神经炎性疼痛的研究。 | |||
T21980 |
PD 198306
|
MEK | MAPK |
PD 198306 是一种具有抗痛觉过敏作用的 MAPK/ERK 激酶 (MEK) 选择性抑制剂。 PD 198306 可降低链脲佐菌素诱导的活性 ERK1 水平升高。 | |||
T0916 |
Butamben
Butyl 4-aminobenzoate,4-氨基苯甲酸丁酯 |
Potassium Channel; Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
Butamben (Butyl 4-aminobenzoate) 是一种长效局部麻醉剂,用于治疗慢性疼痛。 | |||
T16164 |
MY-5445
N-(3-chlorophenyl)-4-phenylphthalazin-1-amine |
PDE | Metabolism |
MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) 是特异性的 cGMP 磷酸二酯酶 PDE5抑制剂,其 Ki=1.3 μM。它是一种 ABCG2转运蛋白调节剂,具有抗增殖活性。它能抑制人血小板凝集。 | |||
T0386L |
Ropivacaine
LEA-103 HCl,罗哌卡因 |
Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Ropivacaine (LEA-103 HCl) 是有效的钠通道阻断剂,通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine 也是一种 K2P(双孔钾通道)TREK-1的抑制剂,在 COS-7 细胞膜上的 IC50值为 402.7 μM。Ropivacaine 可以用于神经性疼痛的缓解的相关研究。 | |||
T6950 |
PNU-120596
NSC 216666 |
AChR | Neuroscience |
PNU-120596 (NSC-216666) 是一种选择性α7 nAChR 阳性变构调节剂,EC50为 216 nM,可用于精神病和神经疾病的研究。 | |||
T6551 |
Isosorbide
Devicoran,Isobide,异山梨酯,异山梨醇,Hydronol,Dianhydro-D-glucitol,D-Isosorbide |
Others | Others |
Isosorbide (Devicoran) 是一种血管舒张剂,也是一种高渗利尿剂,口服具有活性。可用于研究心力衰竭和心绞痛(胸痛)。 | |||
T0386 |
Ropivacaine hydrochloride
盐酸罗哌卡因,Ropivacaine monohydrochloride |
Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Ropivacaine hydrochloride (Ropivacaine monohydrochloride) 是钠通道阻断剂,通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine hydrochloride 也是 K2P(双孔钾通道)TREK-1的抑制剂。在动物实验模型中,Ropivacaine hydrochloride 可用于神经性疼痛的缓解。 | |||
T23008L |
MMPIP hydrochloride
MMPIP hydrochloride (479077-02-6 Free base) |
GluR | Neuroscience |
MMPIP hydrochloride 是变构 mGluR7 的选择性拮抗剂。 MMPIP hydrochloride 可用于研究 mGluR7 对中枢神经系统功能的作用。 | |||
T15781 |
LP-935509
|
Serine/threonin kinase; AAK1 (AP2 associated kinase 1) | Cell Cycle/Checkpoint; Metabolism; Neuroscience |
LP-935509 是一种选择性的、具有脑渗透的、小分子的衔接蛋白-2 相关激酶1 (AAK1) ATP 竞争性抑制剂,其 IC50=3.3 nM,Ki=0.9 nM。它是一种 BIKE 的有效抑制剂 (IC50=14 nM) 和中度的 GAK 抑制剂 (IC50=320 nM)。它能够逆转 SNL 手术后的疼痛。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2239 |
Strictosamide
异长春花苷内酰胺 |
ATPase; Potassium Channel; Sodium Channel; Parasite; Antifungal | Membrane transporter/Ion channel; Microbiology/Virology |
Strictosamide 具有抗炎、抗疟原虫和抗真菌活性。 | |||
T3S2312 |
Poncirin
枸橘苷,Isosakuranetin-7-neohesperidoside |
Apoptosis; Others | Apoptosis; Others |
Poncirin (Isosakuranetin-7-neohesperidoside) 是从三叶草中分离出来的一种天然产物,具有抗炎活性。 它防止脂肪生成,增强间充质干细胞中的成骨细胞分化,增加骨矿物质密度,改善小梁微结构,可能反映 GIO 小鼠的骨形成增加和骨吸收减少。 | |||
T4S0537 |
Neoline
Bullatine B,雪上一枝蒿乙素 |
Others; Sodium Channel | Membrane transporter/Ion channel; Others |
Neoline 是一种乌头根 (PA) 的活性成分,可改善奥沙利铂引起的小鼠周围神经病变。Neoline 通对Nav1.7 电压门控钠通道电流 (VGSC)有抑制作用。它可用作标记化合物,从而测定用于研究神经性疼痛的 PA 产品的质量。 | |||
TN6794 |
N-(3-methoxybenzyl)-octadecanamide
|
Others | Others |
N-(3-methoxybenzyl)-octadecanamide 从玛卡 (Lepidium meyenii Walp.) 转化而来。 | |||
T3S0870 |
Paederosidic acid methyl ester
鸡屎藤苷酸甲酯,紫草酸甲酯 |
ATPase; Potassium Channel; NO Synthase | Immunology/Inflammation; Membrane transporter/Ion channel |
Paederosidic acid methyl ester 是 ATP 敏感的 K+channel 通道激活剂,分离自 P. scandens。它通过激活脑中和脊髓水平中 ATP 敏感型 K+通道提高了痛觉阈值,表现出显著的中枢缓解疼痛活性。 | |||
T9352 |
hydrocotarnine
|
Others | Others |
hydrocotarnine 是 Cbl 的抑制剂。 | |||
T3026 |
(-)-Huperzine A
HupA,石杉碱,Huperzine A,石杉碱甲 |
Apoptosis; AChR; AChE; iGluR | Apoptosis; Membrane transporter/Ion channel; Neuroscience |
(-)-Huperzine A (HupA) 是从中国梅花苔中分离得到的一种生物碱,具有神经保护活性。它是高特异性可逆的,具有血脑屏障渗透性的一种乙酰胆碱酯酶抑制剂, 其IC50值为 82 nM。 它也是 N-甲基-D-天冬氨酸受体的非竞争性拮抗剂,可研究神经退行性疾病,如阿尔茨海默病。 | |||
T19503 |
Papain
|
Others; Cysteine Protease | Others; Proteases/Proteasome |
Papain 是一种半胱氨酸蛋白酶,是肽酶 C1 家族中一员,在食品、医药、化妆品、纺织等具有广泛的应用。 | |||
T10685 |
Carpaine
|
Others | Others |
Carpaine, an alkaloid isolated from Carica papaya Linn, has anti-thrombocytopenic activity. It has the anti-plasmodial activity to prevent malaria. | |||
TN5757 |
p-Hydroxybenzaldehyde glucoside
4-formylphenyl b-d-glucopyranoside,Gastrodin Impurity |
||
p-Hydroxybenzaldehyde glucoside (4-formylphenyl b-d-glucopyranoside) 是抑制天麻素衍生物,具有镇痛活性,可以用于研究神经源性疼痛。 | |||
T3154 |
Citral
Geranialdehyde,alpha-Citral,柠檬醛,geranial |
Others | Others |
Citral 是一种单萜,从柠檬草精油中获得,具有抗疼痛、抗炎作用。 | |||
T20225 |
Dicentrine, (-)-
L-Dicentrine,荷包牡丹碱,NSC 251699,NSC251699,NSC-251699 |
Others | Others |
Dicentrine, (-)- (NSC-251699) 是一种在几种植物物种中发现的非卟啉生物碱,在小鼠内脏痛的急性模型中显示出显著的镇痛活性。 | |||
T3820 |
Iridin
野鸢尾苷,Lridin |
Others | Others |
Iridin (Lridin) 是抑制异黄酮化合物,从Iris milesii 中提取得到。 | |||
TN6778 |
Umbelliprenin
伞形花醚,7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin |
IL Receptor | Immunology/Inflammation |
Umbelliprenin (7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin) 可减轻神经性疼痛,并降低血清 IL-6 水平和氧化应激。 | |||
T12139 |
N-(3-Methoxybenzyl)Palmitamide
N-(3-甲氧基苄基)十六碳酰胺,玛卡酰胺杂质5 |
FAAH | Metabolism; Neuroscience |
N-(3-Methoxybenzyl)Palmitamide 是FAAH 抑制剂,可用于研究疼痛,炎症和中枢神经系统退行性疾病。 | |||
T7106 |
Menaquinone-4
四烯甲萘醌,Vitamin K2,Menaquinone K4 |
Others; Endogenous Metabolite | Metabolism; Others |
Menaquinone-4 (Vitamin K2) 是维生素 K 的一种,用作止血剂,有潜力用于骨质疏松的研究。 | |||
TN1594 |
DL-Syringaresinol
(±)-Syringaresinol |
Antioxidant; Antifungal | Microbiology/Virology; oxidation-reduction |
DL-Syringaresinol ( (±)-Syringaresinol) 是一种来自与人参浆果的木质素,具有抗炎、抗氧化、镇痛活性和较弱的抗分枝杆菌活性。DL-Syringaresinol 可通过自噬延缓氧化应激诱导的皮肤老化,通过抑制炎症反应来缓解奥沙利铂诱导的神经性疼痛和脓毒症引起的心功能障碍。 | |||
T3896 |
Shanzhiside methyl ester
三栀子甙甲酯,山芝皂苷甲酯 |
Glucagon Receptor | GPCR/G Protein |
Shanzhiside methyl ester 是一种小分子胰高血糖素样肽 1 受体激动剂,分离自轮状乳杆菌,能够诱导抗异常性痛觉耐受。 | |||
T5S0229 |
Isosakuranetin
4'-Methylnaringenin,异野樱素,异樱花亭 |
Others | Others |
Isosakuranetin (4'-Methylnaringenin) 是一种黄烷酮黄酮类化合物,存在于 Citrus bergamia 果实中。 | |||
TWS1293 |
Angelic anhydride
2-Methylisocrotonic Anhydride,当归酸酐,(Z)-2-Methylbut-2-enoic anhydride |
Others | Others |
Angelic anhydride ((Z)-2-Methylbut-2-enoic anhydride) 是一种脂肪酸酐,来自于不饱和碳氢酸酐。 | |||
TQ0240 |
6"-O-Apiosyl-5-O-Methylvisammioside
|
Others | Others |
6”-O-Apiosyl-5-O-Methylvisammioside 是中药颈复康的成分之一,颈复康具有活血通络,散风止痛的作用。 | |||
T5786 |
TETRAHYDROPIPERINE
四氢胡椒碱,Cosmoperine |
P450; TRP/TRPV Channel | Membrane transporter/Ion channel; Metabolism |
Tetrahydropiperine (Cosmoperine) 是胡椒碱的环己基类似物,也是一种天然芳基戊酰胺,从Piper longum 分离得到。它对细胞色素 P450 (CYP) 同工型 CYP1A1/芳基烃羟化酶 (AHH;IC50=23 µM)具有抑制作用。 | |||
T2163 |
Dihydrocapsaicin
CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide |
Others; TRP/TRPV Channel | Membrane transporter/Ion channel; Others |
Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素,是TRPV1的选择性激动剂,同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。 | |||
TN3174 |
6-Methoxyflavanone
NSC50184 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
6-Methoxyflavanone(6-MeOF)是人重组GABA A受体GABA反应的正变构调节剂,具有抗焦虑活性和抗炎活性,可用于减轻顺铂诱导的神经性疼痛。 | |||
TN6791 |
Palvanil
Hexadecanamide |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Palvanil (Hexadecanamide) 是一种快速脱敏的 TRPV1 激动剂。它可能是治疗 IBS 的有前途的药物,因为它可以调节肠道蠕动并减轻内脏疼痛。 | |||
T0004 |
Salicylamide
水杨酰胺,Salamide,2-Hydroxybenzamide |
COX | Immunology/Inflammation; Neuroscience |
Salicylamide(2-Hydroxybenzamide) 是一种止痛剂和抗热解药剂,是一种微粒体 UDP-葡糖醛酸基转移酶抑制剂。 | |||
T0399 |
Methyl salicylate
Gaultheria oil,Methyl 2-hydroxybenzoate,2-Carbomethoxyphenol,Betula oil,水杨酸甲酯,Natural wintergreen oil,Wintergreen oil |
COX; TRP/TRPV Channel | Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Methyl salicylate (Gaultheria oil) 是从番泻叶中提取的一种天然三萜皂苷,是一种局部缓解疼痛和抗炎作用的药物。 它还用作食品和烟草制品中的农药、变性剂、香料成分和调味剂。 | |||
TMO2713 |
4(3H)-Quinazolinone
Quinazolin-4-ol,4-Hydroxyquinazoline,4-羟基喹唑啉,4-Quinazolinol,4-Quinazolone,4-Quinazolinone |
Antibacterial; Platelet aggregation | Microbiology/Virology; Others |
4(3H)-Quinazolinone (4-Hydroxyquinazoline) 是化学合成中的砌块,是一种生物活性氮杂环化合物。它具有多种生物学特性,如抗菌,抗真菌,抗惊厥,抗炎,抗 HIV,抗癌和缓解疼痛活性。 | |||
T2698 |
Asperosaponin VI
Akebia saponin D,Asperosaponin Ⅵ,川续断皂苷 VI |
Apoptosis; Others; Caspase | Apoptosis; Others; Proteases/Proteasome |
Asperosaponin VI (Akebia saponin D) 是一种来自续断壁的皂苷组分。它通过增加 Bcl-2/Bax 比值,降低活性 caspase-3 表达,以及增强 p-Akt 和 p-CREB,从而抑制缺氧诱导的心肌细胞凋亡。它通过 BMP-2/p38 和 ERK1/2 信号途径诱导成骨细胞分化。 | |||
T3S2105 |
N-Benzylpalmitamide
Macamide 1,玛卡酰胺 B,N-苄基十六烷酰胺,N-Benzylhexadecanamide |
Others; FAAH; Autophagy | Autophagy; Metabolism; Neuroscience; Others |
N-Benzylpalmitamide (Macamide 1) 是从玛卡中得到的一种生物碱,可以时间依赖性方式抑制脂肪酸酰胺水解酶,有治疗疼痛、炎症和中枢神经系统退行性疾病的研究潜力。 | |||
T3S2296 |
Gardenoside
羟异栀子苷,栀子苷 |
Others | Others |
Gardenoside 是一种发现于栀子中的天然化合物,具有保肝作用。它对 FFA 诱导的细胞脂肪变性有抑制作用。它可以调节 P2X3 和 P2X7 受体来抑制慢性缩痛。 | |||
T2S0490 |
Eugenol acetate
Acetyleugenol,乙酰丁香酚,Aceteugenol,乙酸丁香酚酯,Eugenyl acetate,1,3,4-Eugenol acetate |
Others; Antibacterial; Antifungal | Microbiology/Virology; Others |
Eugenol acetate (Aceteugenol) 是来自丁香植物 Syzygiumaromaticum 的一种化学成分,具有抗菌、抗毒和抗氧化活性。 | |||
T4779 |
4-Methylcatechol
p-Methylcatechol,3,4-二羟基甲苯,Homocatechol,4-methylbenzene-1,2-diol,3,4-Dihydroxytoluene |
Others; Endogenous Metabolite | Metabolism; Others |
4-Methylcatechol (3,4-Dihydroxytoluene) 是 p-toluate 的代谢物,它是 Catechol 2,3-Dioxygenase 的自杀性底物抑制剂。 | |||
T5562 |
Methyl nicotinate
烟酸甲酯,methyl pyridine-3-carboxylate |
Others | Others |
Methyl nicotinate (methyl pyridine-3-carboxylate) 是一种盐酸甲酯,发现于酒精饮料中,在非处方局部制剂中用作活性成分,用于研究肌肉和关节疼痛。 | |||
T0884 |
1-Docosanol
Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol |
Antifection; HSV | Microbiology/Virology |
1-Docosanol (Behenic alcohol) 是一种具有抗病毒活性的饱和 22 碳脂肪醇,局部用于治疗复发性单纯性唇疱疹发作并缓解相关疼痛并可能有助于更快地治愈疮。 | |||
T5S0661 |
Koumine
|
Others | Others |
Koumine 是一种从钩吻中得到的生物碱,具有高效抗肿瘤活性,在肿瘤细胞中能够提高 Bax/Bcl-2 的蛋白比例和 caspase-3 的表达。在类风湿性关节炎动物模型中,它能够预防关节炎的发展。它具有抗焦虑、抗应激、抗银屑病作用,也可用于缓解疼痛的研究。 | |||
T6S1653 |
Albiflorin
Alibiflorin,芍药内酯苷 |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Albiflorin (Alibiflorin) 是一种牡丹根中的主要成分,是一种单萜糖苷。它具有神经保护、抗炎、抗氧化和缓解疼痛作用。 | |||
T2768 |
Saikosaponin A
柴胡皂苷A,柴胡皂苷 A |
NF-κB; Antibacterial; Liver X Receptor | Metabolism; Microbiology/Virology; NF-κB |
Saikosaponin A 是银柴胡中的主要活性成分,有抗炎活性,可上调 LXRα的表达。 | |||
T4447 |
S-(5'-Adenosyl)-L-methionine tosylate
S-腺苷蛋氨酸对甲苯磺酸盐,SAMe,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt |
Others | Others |
S-(5'-Adenosyl)-L-methionine tosylate (SAMe) 是一种普遍存在的甲基供体,参与多种生物反应,包括由 DNA 和蛋白质甲基转移酶介导的反应。它可改善抑郁、与骨关节炎和纤维肌痛相关的疼痛以及肝毒性。 | |||
TN1308 |
6-Hydroxyflavanone
|
Others; Lipoxygenase; COX; GABA Receptor | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others |
6-Hydroxyflavanone 是从菖蒲叶中提取分离,通过靶向环氧合酶-2(COX-2),5-脂氧合酶(5-LOX)以及阿片类药物和 GABA-A 受体从而具有抗炎和抗神经性疼痛活性。6-Hydroxyflavanone 在链脲佐菌素诱导的糖尿病神经病变模型中具有抗伤害感受特性。 | |||
T2S2362 |
Dehydrocorydaline nitrate
去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱 |
BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome |
Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达,激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌、抗疟疾等功效。 | |||
T2520 |
Desloratadine
Sch34117,地氯雷他定,NSC 675447 |
Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Desloratadine (Sch34117) 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物,可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用,包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂,具有抗过敏和抗炎活性。 | |||
T4S0969 |
Obtusifolin
决明蒽醌,决明蒽醌;美决明子素 |
Antioxidant; NF-κB | NF-κB; oxidation-reduction |
Obtusifolin 是分离自决明子的种子中,能够抑制NF-kB 通路,调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。 | |||
T3S2259 |
Methyl eugenol
4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物,存在于植物叶子、果实、根茎中,当植物相应的部位因食草动物进食而受损时,就会释放。它可用于消灭雄性东方果蝇。 | |||
TN7339 |
Murracarpin
|
Others | Others |
Murracarpin exhibits vasorelaxing, antinociceptive (pain-blocking), and anti-inflammatory properties. | |||
T35614 |
D-Trimannuronic acid
|
Others | Others |
D-Trimannuronic acid is an alginate oligomer that originates from seaweed. It can induce TNF-α secretion by mouse macrophage cell lines, making it valuable in pain and vascular dementia research [1][2][3]. | |||
TN1000 |
Solasurine
|
Others | Others |
Solasurine is a natural product with dissipate blood stasis and detumescence, relieve pain and pull poison. | |||
T38981 |
D-Tetramannuronic acid
|
Others | Others |
D-Tetramannuronic acid, an alginate oligomer, is derived from marine brown algae and certain Gram negative bacteria. It serves as a valuable compound for pain and vascular dementia research[4]. | |||
T4116 |
S-Adenosyl-DL-Methionine
Ademetionine,S-腺苷蛋氨酸,S-ADENOSYL-L-METHIONINE |
Others | Others |
S-Adenosyl-DL-Methionine (Ademetionine) 是一种 Ademetionine 的衍生物。其中Ademetionine 是蛋氨酸的中间代谢产物。 | |||
T39277 |
D-Hexamannuronic acid
|
Others | Others |
D-Hexamannuronic acid, an alginate oligomer, is derived from marine brown algae and a restricted group of Gram negative bacteria. This compound serves as a valuable tool for investigating pain and vascular dementia[4]. | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00347 |
Papain Protein, Carica papaya, Recombinant (His)
Papain,Papaya proteinase I |
Carica papaya | E. coli |
Papain Protein, Carica papaya, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.4 kDa and the accession number is P00784. | |||
TMPH-03156 |
Lys-gingipain Protein, Porphyromonas gingivalis, Recombinant (His & SUMO)
Lysine-specific cysteine proteinase Kgp,Lys-gingipain |
Porphyromonas gingivalis | E. coli |
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria. Lys-gingipain Protein, Porphyromonas gingivalis, Recombinant (His & SUMO) is expressed in E. col... | |||
TMPH-03155 |
Lys-gingipain HG66 Protein, Porphyromonas gingivalis, Recombinant (His & Myc)
Lys-gingipain HG66,kgp |
Porphyromonas gingivalis | E. coli |
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria. Lys-gingipain HG66 Protein, Porphyromonas gingivalis, Recombinant (His & Myc) is expressed in E.... | |||
TMPH-03577 |
Staphopain B Protein, S. aureus, Recombinant (GST)
Staphopain B,sspB,Staphylopain B,Staphyloc... |
Staphylococcus aureus | E. coli |
Cysteine protease that plays an important role in the inhibition of host innate immune response. Degrades host elastin, fibrogen, fibronectin and kininogen. Blocks phagocytosis of opsonised S. aureus by neutrophils and monocytes by inducing their death in a proteolytic activity-dependent manner. Decreases surface expression of the 'don't eat me' signal CD31 on neutrophils. Cleaves host galectin-3/LGALS3, thereby inhibiting the neutrophil-activating ability of the lectin. Staphopain B Protein, S.... | |||
TMPH-03154 |
Lys-gingipain 381 Protein, Porphyromonas gingivalis, Recombinant (His)
kgp,Lys-gingipain 381 |
Porphyromonas gingivalis | E. coli |
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria. Lys-gingipain 381 Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in E. coli e... | |||
TMPH-03599 |
Streptopain Protein, S. pyogenes, Recombinant (His & SUMO)
Group A streptococcal cysteine protease,SPE B,Streptococcus ... |
Streptococcus pyogenes | E. coli |
Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing. Streptopain Protein, S. pyogenes, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO... | |||
TMPY-05945 |
Influenza A H1N2 (A/Swine/Spain/SF12091/2007) Neuraminidase/NA Protein (His)
|
H1N2 | HEK293 Cells |
Influenza A H1N2 (A/Swine/Spain/SF12091/2007) Neuraminidase/NA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.6 kDa and the accession number is R4ZD61. | |||
TMPY-05682 |
SARS-CoV-2 Plpro/papain-like protease Protein (aa 1564-1880, His)
|
SARS-CoV-2 | E. coli |
SARS-CoV-2 Plpro/papain-like protease Protein (aa 1564-1880, His) is expressed in E. coli expression system. The predicted molecular weight is 36.79 kDa and the accession number is QVD65746.1. | |||
TMPY-04894 |
SARS-CoV (strain WH20) Plpro/papain-like protease (His)
|
SARS | E. coli |
SARS-CoV (strain WH20) Plpro/papain-like protease (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 36.65 kDa and the accession number is AAX16193.1. | |||
TMPY-05892 |
Influenza A H3N2 (A/swine/Spain/33601/2001) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H3N2 | HEK293 Cells |
Influenza A H3N2 (A/swine/Spain/33601/2001) Hemagglutinin/HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.8 kDa and the accession number is Q288R9. | |||
TMPH-03648 |
Cruzipain Protein, Trypanosoma cruzi, Recombinant (His & Myc)
Cruzaine,Cruzipain,Major cysteine proteinase |
Trypanosoma cruzi | E. coli |
Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group.; The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. Cruzipain Protein, Trypanosoma cruzi, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weig... | |||
TMPH-03151 |
Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (His)
Gingipain 1,Gingipain R1,RGP-1,Arg-gingi |
Porphyromonas gingivalis | P. pastoris (Yeast) |
Thiol protease. Acts synergistically with RgpB to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms (Probable). Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 56.0 kDa and the accession number is P28784. | |||
TMPH-03152 |
Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (B2M & His)
RGP-1,Arg-gingipain,Gingipain R1,Gingi... |
Porphyromonas gingivalis | E. coli |
Thiol protease. Acts synergistically with RgpB to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms (Probable). Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 68.0 kDa and the accession number is P28784. | |||
TMPH-03598 |
Streptopain Protein, S. pyogenes serotype M28, Recombinant (His & SUMO)
SPE B,Streptococcus peptidase A,Streptopain,Strepto... |
Streptococcus pyogenes | E. coli |
Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing. Streptopain Protein, S. pyogenes serotype M28, Recombinant (His & SUMO) is expressed in E. coli expression system with... | |||
TMPH-03153 |
Gingipain R2 Protein, Porphyromonas gingivalis, Recombinant (His)
rgpB,Gingipain 2,RGP-2,Arg-gingipain,Gingi... |
Porphyromonas gingivalis | E. coli |
Thiol protease. Acts synergistically with RgpA to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms. Gingipain R2 Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in E. coli expression system with C-10xHis tag. The predicted molecular weight is 57.1 kDa and the accession number is P95493. | |||
TMPJ-01431 |
SARS-CoV-2 Papain-Like Protease Protein
PLpro,PL-PRO,pp1a,Replicase polyprotein 1a,Papain-l... |
SARS-CoV-2 | E. coli |
Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) sect... | |||
TMPK-01352 |
SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi)
Plpro,PL2-PRO,pp1a,nsp1,Replicase polyprotein 1a,Papain<... |
SARS | E. coli |
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS-CoV-2 PLpro/papain-like protease Pro... | |||
TMPK-01384 |
SARS PLpro/papain-like protease Protein (His)
Papain-like Protease,PL-PRO,Replicase polyprotein 1... |
SARS | E. coli |
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS PLpro/papain-like protease Protein (... | |||
TMPH-03576 |
Staphopain A Protein, S. aureus, Recombinant (His & Myc)
Staphopain A,Staphylopain A,sspP,Staphyloc... |
Staphylococcus aureus | E. coli |
Staphopain A Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.4 kDa and the accession number is P81297. | |||
TMPH-02414 |
Lys-gingipain W83 Protein, Porphyromonas gingivalis, Recombinant (His)
Lys-gingipain W83,Lysine-specific cysteine proteina... |
Porphyromonas gingivalis | E. coli |
Lys-gingipain W83 Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in E. coli expression system with C-10xHis tag. The predicted molecular weight is 51.6 kDa and the accession number is Q51817. | |||
TMPK-00735 |
CXCL13/BCA-1 Protein, Mouse, Recombinant (His)
ANGIE,BLR1L,ANGIE2,BLC,SCYB13,BCA1,BCA-1 |
Mouse | HEK293 Cells |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The pred... | |||
TMPK-00541 |
SEZ6 Protein, Cynomolgus, Recombinant (His)
SEZ-6,BSRPC,BSRP-C,SEZ6 |
Cynomolgus | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weig... | |||
TMPK-00997 |
SEZ6 Protein, Human, Recombinant (hFc)
SEZ-6,BSRP-C,SEZ6,BSRPC |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is... | |||
TMPK-01065 |
SEZ6 Protein, Mouse, Recombinant (His)
BSRP-C,SEZ-6,BSRPC,SEZ6 |
Mouse | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is... | |||
TMPK-00018 |
CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo)
BLC,SCYB13,ANGIE,ANGIE2,BCA-1,BLR1L,BCA1 |
Human | E. coli |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo) is expressed in E. coli expression system with N-His-Sum... | |||
TMPH-02118 |
SCN1A Protein, Human, Recombinant (His)
Sodium channel protein brain I subunit alpha,Sodium channel ... |
Human | E. coli |
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neur... | |||
TMPK-00998 |
SEZ6 Protein, Human, Recombinant (His)
BSRPC,BSRP-C,SEZ-6,SEZ6 |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is... | |||
TMPK-00017 |
CXCL13/BCA-1 Protein, Human, Recombinant (hFc)
BCA1,BLR1L,BLC,SCYB13,ANGIE2,BCA-1,ANGIE |
Human | HEK293 Cells |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The pred... | |||
TMPK-00996 |
SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated
BSRPC,BSRP-C,SEZ6,SEZ-6 |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predi... | |||
TMPK-00734 |
CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc)
ANGIE,ANGIE2,BCA-1,BLR1L,BLC,BCA1,SCYB13 |
Mouse | HEK293 Cells |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The pred... | |||
TMPH-01764 |
Neuropeptide B Protein, Human, Recombinant (GST)
Neuropeptide B,Preproprotein L7,NPB |
Human | E. coli |
May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Neuropeptide B Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 29.5 kDa and the accession number is Q8NG41. | |||
TMPH-01765 |
Neuropeptide B Protein, Human, Recombinant
Preproprotein L7,NPB,Neuropeptide B |
Human | E. coli |
May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Neuropeptide B Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 3.1 kDa and the accession number is Q8NG41. | |||
TMPH-03337 |
MGLL Protein, Rat, Recombinant (His)
Mgll,Monoacylglycerol lipase,Monoglyceride lipase |
Rat | P. pastoris (Yeast) |
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. MGLL Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 34.8 kDa and the accession nu... | |||
TMPJ-00737 |
PDYN Protein, Human, Recombinant (His)
PDYN,ADCA,Big Dyn,Dynorphin B,PENKB,SCA23 |
Human | HEK293 Cells |
Proenkephalin-B(PDYN), belongs to the opioid neuropeptide precursor family. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. Leu-enkephalins, which is a type of Proenkephalin-B, compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A has a typical o... | |||
TMPH-03035 |
M-myrmeciitoxin-Mp2b Protein, Myrmecia pilosula, Recombinant (GST & His)
DELTA-myrtoxin-Mp1a B chain,Pilosin-3 subunit b,M-myrmeciito... |
Myrmecia pilosula | Baculovirus Insect Cells |
Heterodimer protein that may serve both defensive (pain-inducing) and predatory (insecticidal) roles. Has membrane-disrupting activity and shows induction of non-specific calcium influx into cells,. Shows broad-spectrum activity against a diverse range of bacteria, and cell lines, as well as hemolytic activity (EC(50)=2.18 uM). In vivo, shows moderate insecticidal activity against D.melanogaster and potent anthelmintic activity against the veterinary nematode H.contortus. In addition, intraplant... | |||
TMPJ-00475 |
Kallikrein 1/KLK1 Protein, Human, Recombinant (aa 19-262, His)
Tissue Kallikrein,Kidney/Pancreas/Salivary Gland Kallikrein,... |
Human | HEK293 Cells |
Kallikrein-1 (KLK1) is a member of human tissue Kallikrein family. Human KLK1 precursor contains a singal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262). The function of KLK1 is to cleave Kininogen in order to release the vasoactive Kinin peptide (Lysyl-Bradykinin or Bradykinin). The Kinin peptide controls blood pressure reduction, vasodilation, smooth muscle relaxation and contraction, pain induction and inflammation. KLK1 also plays ... | |||
TMPJ-01277 |
CRT2 Protein, Human, Recombinant
CALR3,Calreticulin-3,calreticulin-2,calsperin,CRT2 |
Human | E. coli |
Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy t... | |||
TMPJ-00733 |
SPINK1 Protein, Human, Recombinant (His)
PSTI,Pancreatic Secretory Trypsin Inhibitor,TATI,Serine Prot... |
Human | HEK293 Cells |
Serine Protease Inhibitor Kazal-Type 1 (SPINK1) is a trypsin inhibitor that prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). Recombinant SPINK1 protein (rSPINK1) stimulated cell proliferation in benign RWPE ... | |||
TMPJ-00009 |
CCL2 Protein, Human, Recombinant
C-C motif chemokine 2,MCAF,CCL2,MCP-1,Monocyte chemotactic p... |
Human | E. coli |
The chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP)-1 and small inducible cytokine A2 (SCYA2)), is a small cytokine that belongs to the CC chemokine family responsible for monocyte attraction. Its cognate receptor, CCR2, play a critical role in regulating nociceptive processes during neuropathic pain. Both CCL2 and CCR2 are implicated in induction of autoimmunity. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation... | |||
TMPY-03963 |
CALCB Protein, Human, Recombinant (mFc)
CGRP-II,calcitonin-related polypeptide β,calcitonin-related ... |
Human | HEK293 Cells |
CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of ... | |||
TMPY-04557 |
PHKG1 Protein, Human, Recombinant (GST)
phosphorylase kinase, γ 1 (muscle),phosphorylase kinase, gam... |
Human | Baculovirus Insect Cells |
Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform, also known as Phosphorylase kinase subunit gamma-1 and PHKG1, is a member of the protein kinase superfamily and CAMK Ser/Thr protein kinase family. PHKG1 is the catalytic member of a 16 subunit protein kinase complex that contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. Muscle glycogenosis caused by phosphorylase kinase (Phk) deficiency may lead to exercise intolerance, ... | |||
TMPJ-00785 |
FABP3 Protein, Human, Recombinant (His)
H-FABP,FABP11,Fatty Acid-Binding Protein Heart,MDGIMuscle Fa... |
Human | E. coli |
Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, FABP3 is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-types. They form 14-15 kDa proteins and are thought to p... | |||
TMPJ-00534 |
hFcgR4 Protein, Mouse, Recombinant (His)
Low Affinity Immunoglobulin γ Fc Region Receptor IV,FcgR4,Lo... |
Mouse | HEK293 Cells |
Fcgr4, also known as CD16-2, is one of the receptors for Fc region of IgG which involve in immune responses. Fcgr4 mainly functions in cellular response to lipopolysaccharide, NK T cell proliferation, regulation of sensory perception of pain, wound healing etc. Three groups are included for Fc γ receptors (FcR), and they are Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). Among these, CD64 possess high affinity even for monomeric IgG, while CD32 and CD16 display a relative lower affinity ... | |||
TMPH-02236 |
TMPRSS2 Protein, Human, Recombinant (E. coli, His)
Transmembrane protease serine 2,TMPRSS2,Serine protease 10 |
Human | E. coli |
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.... | |||
TMPH-02237 |
TMPRSS2 Protein, Human, Recombinant (His & Myc)
Serine protease 10,Transmembrane protease serine 2,TMPRSS2 |
Human | HEK293 Cells |
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.... | |||
TMPY-02181 |
PLA2G12B Protein, Mouse, Recombinant (His)
Fksg71,2010002E04Rik,Pla2g13,hlb218,phospholipase A2, group ... |
Mouse | HEK293 Cells |
Group XIIB secretory phospholipase A2-like protein, also known as Group XIII secretory phospholipase A2-like protein, GXIII sPLA2-like, sPLA2-GXIIB, GXIIB, PLA2G13 and PLA2G12B, is a secreted protein that belongs to the phospholipase A2 family. PLA2G12B / PLA2G13 is strongly expressed in liver, small intestine and kidney. Mammalian secretory phospholipase A2s ( sPLA2s ) form a family of structurally related enzymes that are involved in a variety of physiological and pathological processes via th... | |||
TMPY-02162 |
PLA2G2E Protein, Mouse, Recombinant (His)
phospholipase A2, group IIE,Phospholipase A2 IIE |
Mouse | HEK293 Cells |
Group IIE secretory phospholipase A2, also known as GIIE sPLA2, sPLA2-IIE, Phosphatidylcholine 2-acylhydrolase 2E and PLA2G2E is a secreted protein that belongs to the phospholipase A2 family. Mammalian secretory phospholipase A2s (sPLA2s) form a family of structurally related enzymes that are involved in a variety of physiological and pathological processes via the release of arachidonic acid from membrane phospholipids or the binding to specific membrane receptors. Phospholipases A2 / PLA2 are... | |||
TMPJ-00100 |
Artemin Protein, Human, Recombinant
ARTN,Artemin,EVN,Enovin,Neublastin |
Human | E. coli |
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T71206 |
Tiagabine-d6 hydrochloride
|
||
Tiagabine-d6 is intended for use as an internal standard for the quantification of tiagabine by GC- or LC-MS. Tiagabine is an inhibitor of GABA transporter 1. It inhibits seizures induced by DMCM in mice. Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg, and it acts synergistically with gabapentin to delay pain responses in mice in the hot plate test. Formulations containing tiagabine have been used as adjunctive therapies in the treatment of ... | |||
TMIJ-0270 |
Pinaverium-d4 Bromide (Mixture of Diastereomers)
|
||
Pinaverium-d4 Bromide (Mixture of Diastereomers) 是 Pinaverium Bromide 的氘代化合物。Pinaverium Bromide 的 CAS 号为 53251-94-8。Pinaverium bromide 是一种具有解痉作用的钙通道阻滞剂,可有效缓解疼痛、腹泻和肠道不适。 | |||
TMID-0296 |
Gabapentin-d6 Hydrochloride
|
||
Gabapentin-d6 Hydrochloride 是 Gabapentin Hydrochloride 的氘代化合物。Gabapentin Hydrochloride 的 CAS 号为 60142-95-2。Gabapentin hydrochloride 是GABA类似物,可用于缓解神经性疼痛。 | |||
TMIJ-0210 |
Bupivacaine-d9
|
||
Bupivacaine-d9 是 Bupivacaine 的氘代化合物。Bupivacaine 的 CAS 号为 38396-39-3。Bupivacaine 是一种 NMDA 受体抑制剂。Bupivacaine 可以阻断钠、L-钙和钾通道。Bupivacaine 有效阻断 SCN5A 通道,IC50 为 69.5 μM。Bupivacaine 可用于慢性疼痛的研究。 | |||
T71285 |
Metaxalone-d6
|
||
Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM. Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 in RAW 264.7 cells. Formulations containing metaxalone ... | |||
TMIJ-0207 |
(S)-Ketoprofen-d3
|
||
(S)-Ketoprofen-d3 是 (S)-Ketoprofen 的氘代化合物。(S)-Ketoprofen 的 CAS 号为 22161-81-5。S-(+)-Ketoprofen 抑制COX-1和COX-2的IC50值分别为 1.9 和 27 nM。 | |||
TMIH-0205 |
Duloxetine-d3 HCl
|
||
Duloxetine-d3 HCl 是 Duloxetine HCl 的氘代化合物。Duloxetine HCl 的 CAS 号为 136434-34-9。Duloxetine hydrochloride 是一种 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI),Ki=4.6 nM,可用于广泛性焦虑症的研究。 | |||
TMIJ-0042 |
Metoprolol-d7 Hydrochloride
|
||
Metoprolol-d7 Hydrochloride 是 Metoprolol Hydrochloride 的氘代化合物。Metoprolol Hydrochloride 的 CAS 号为 56392-18-8。Metoprolol 是一种选择性 β1 受体阻滞剂。Metoprolol 用于治疗高血压、因心脏血流不畅而引起的胸痛以及许多心率异常快的疾病。 | |||
TMIH-0163 |
Clidinium Bromide-d5
|
||
Clidinium Bromide-d5 是 Clidinium Bromide 的氘代化合物。Clidinium Bromide 的 CAS 号为 3485-62-9。Clidinium bromide 是季胺抗毒蕈碱剂,可通过减少胃酸和减慢肠道速度,缓解痉挛和腹部疼痛的症状。 | |||
TMIJ-0044 |
Carbamazepine-d10
|
||
Carbamazepine-d10 是 Carbamazepine 的氘代化合物。Carbamazepine 的 CAS 号为 298-46-4。Carbamazepine是与三环抗抑郁药化学相关的三环化合物,具有抗惊厥和镇痛特性。它通过减少多突触反应和阻断强直后增强发挥其抗惊厥活性。 它通常用于治疗与三叉神经痛相关的疼痛。 | |||
TMIJ-0240 |
Lacosamide-d3 (Acetyl-d3)
|
||
Lacosamide-d3 (Acetyl-d3) 是 Lacosamide 的氘代化合物。Lacosamide 的 CAS 号为 175481-36-4。Lacosamide是一种功能化氨基酸。Lacosamide以一种新的方式调节钠通道:它选择性地增强钠通道缓慢失活,而对快速失活没有影响Lacosamine在不同的啮齿类动物癫痫发作模型中显示出抗癫痫作用,在反映神经性疼痛和慢性炎性疼痛的不同类型和症状的实验动物模型中显示了抗伤害潜力。 | |||
T71212 |
Lornoxicam-d4
|
||
Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e... | |||
TMID-0247 |
LacosaMide-d3
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LacosaMide-d3 是 LacosaMide 的氘代化合物。LacosaMide 的 CAS 号为 175481-36-4。Lacosamide是一种功能化氨基酸。Lacosamide以一种新的方式调节钠通道:它选择性地增强钠通道缓慢失活,而对快速失活没有影响Lacosamine在不同的啮齿类动物癫痫发作模型中显示出抗癫痫作用,在反映神经性疼痛和慢性炎性疼痛的不同类型和症状的实验动物模型中显示了抗伤害潜力。 | |||
TMIJ-0202 |
Desloratadine-d5
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Desloratadine-d5 是 Desloratadine 的氘代化合物。Desloratadine 的 CAS 号为 100643-71-8。Desloratadine 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物,可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用,包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂,具有抗过敏和抗炎活性。 |