Daun02

Name: Daun02
Brand: TargetMol
SKU: T15054
Price: -1 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T15054Cas号 290304-24-4

Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.

还可以

产品编号 T15054Cas号 290304-24-4

Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.

规格	价格	库存	数量
25 mg	¥ 7,240	期货

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产品介绍

生物活性

产品描述	Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
体外活性	Daun02 is converted by β-galactosidase to Daunorubicin, which has been shown to reduce Ca2+-dependent action potentials in neuroblastoma cells [1]. Daun02 is a good substrate for β-galactosidase (β-gal) and it also is a topoisomerase inhibitor [2]. The concentration of Daun02 producing 50% (EC50) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively [3].
体内活性	Daun02 is a good substrate for β-gal (Km and Vmax: 0.37 mM; protein: 8.6 μmol/min/mg). Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin, at a concentration of 10 μM [3].

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 100 mg/mL (113.02 mM)

溶液配制表