PROTAC Sirt2 Degrader-1

Name: PROTAC Sirt2 Degrader-1
Brand: TargetMol
SKU: T16667
Price: 595 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T16667Cas号 2098487-75-1

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].

PROTAC Sirt2 Degrader-1

还可以

产品编号 T16667Cas号 2098487-75-1

规格	价格	库存	数量
100 mg	询价	期货
500 mg	询价	期货

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产品介绍

生物活性

产品描述	PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].
靶点活性	SIRT2:0.25 μM
体外活性	PROTAC Sirt2 Degrader-1 (Compound 12; 10 μM, 1-6 hours) induces Sirt2 degradation in HeLa cells[1].

化学信息

分子量	852.94
分子式	C₄₀H₄₀N₁₀O₈S₂
CAS No.	2098487-75-1
密度	1.52 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 100 mg/mL (117.24 mM)

溶液配制表

	1mg	5mg	10mg	50mg
1 mM	1.1724 mL	5.8621 mL	11.7242 mL	58.6208 mL
5 mM	0.2345 mL	1.1724 mL	2.3448 mL	11.7242 mL
10 mM	0.1172 mL	0.5862 mL	1.1724 mL	5.8621 mL
20 mM	0.0586 mL	0.2931 mL	0.5862 mL	2.9310 mL
50 mM	0.0234 mL	0.1172 mL	0.2345 mL	1.1724 mL
100 mM	0.0117 mL	0.0586 mL	0.1172 mL	0.5862 mL