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Omberacetam

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产品编号 T7108Cas号 157115-85-0
别名 SGS-111, Noopept, GVS-111

Omberacetam (Noopept) 是一种可作为膳食补充剂的合成二肽,有促智和提高认知作用。

Omberacetam
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Omberacetam

Rating icon 很棒
产品编号 T7108 别名 SGS-111, Noopept, GVS-111Cas号 157115-85-0

Omberacetam (Noopept) 是一种可作为膳食补充剂的合成二肽,有促智和提高认知作用。

规格价格库存数量
2 mg¥ 198现货
5 mg¥ 328现货
10 mg¥ 528现货
25 mg¥ 1,060现货
50 mg¥ 1,730现货
100 mg¥ 2,660现货
200 mg¥ 3,890现货
500 mg¥ 6,170现货
1 mL x 10 mM (in DMSO)¥ 363现货
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产品介绍

生物活性
产品描述
Omberacetam (Noopept) is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other related racetam compounds.
体外活性
Omberacetam(以10 μM浓度加入培养基,于Аβ 25-35前72小时)对Аβ 25-35(5 μM,24小时)诱导的PC12细胞损伤的神经保护作用进行了研究。考察了化合物对由Аβ 25-35引起的细胞活性、钙稳态、ROS水平、线粒体功能、tau蛋白磷酸化以及神经突起生长损伤的保护能力。PC12细胞暴露于Аβ 25-35后,观察到ROS水平、细胞内钙和Ser396处tau蛋白磷酸化水平的增加;这些改变伴随着细胞活性下降和凋亡增加。Omberacetam处理改善了PC12细胞的存活率,降低了早期和晚期凋亡细胞的数量,减少了细胞内活性氧和钙的水平,提高了线粒体膜电位。此外,Omberacetam预处理显著减轻了Аβ25-35引起的tau蛋白在Ser396处的过度磷酸化,并改善了神经突起生长的变化。
体内活性
Noopept在长期(21天)治疗后通过提高受训动物的百分比[2],消除了学习性无助的表现。
细胞实验
PC12 cells were cultured routinely at 37°C in DMEM medium, supplemented with 10% fetal bovine serum (FBS), 5% horse serum, 2 mM L-glutamine, 50 μg/ml gentamicin. To induce PC12 differentiation, NGF (50 ng/ml) was added to the DMEM containing 1% FBS, followed by a 5-day incubation. Differentiated PC12 (dPC12) cells were pretreated with noopept at concentration of 10 μM for 72 h, then cells were rinsed with the medium and exposed to amyloid-β-peptide (Аβ25–35;5 μM) for 24 h. Untreated cells were used as control[1].
动物实验
Experiments were carried out on adult outbred albino male rats (n=376; 250-300 g) kept under vivarium conditions with 12-h light period with free access to water and standard food. The operant training was performed in a modified setup for active avoidance conditioning under conditions of uncertain environment.The animals were intraperitoneally injected (1 ml/kg) with noopept (0.1, 0.5, and 1.0 mg/kg) and piracetam (100, 300, and 500 mg/kg; reference drug), afobazol (1, 5, and 10 mg/kg), and buspiron (0.5, 1.0, and 5.0 mg/kg; reference drug) and diazepam (0.05, 0.1, and 0.5 mg/kg; reference drug). Control rats were injected with the same volume of saline. Stability of active avoidance behavior was tested after 48 h and 7 days. The animals with learned helplessness neurosis were injected with noopept and afobazol for 21 days, after which stability of the active avoidance behavior was repeatedly tested[2].
别名SGS-111, Noopept, GVS-111
化学信息
分子量318.37
分子式C17H22N2O4
CAS No.157115-85-0
SmilesCCOC(=O)CNC(=O)C1CCCN1C(=O)CC1=CC=CC=C1
密度1.202g/cm3
储存&溶解度
存储keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 100 mg/mL (314.10 mM)
溶液配制表
1mg5mg10mg50mg
1 mM3.1410 mL15.7050 mL31.4100 mL157.0500 mL
5 mM0.6282 mL3.1410 mL6.2820 mL31.4100 mL
10 mM0.3141 mL1.5705 mL3.1410 mL15.7050 mL
20 mM0.1570 mL0.7852 mL1.5705 mL7.8525 mL
50 mM0.0628 mL0.3141 mL0.6282 mL3.1410 mL
100 mM0.0314 mL0.1570 mL0.3141 mL1.5705 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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