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Omberacetam (Noopept) 是一种可作为膳食补充剂的合成二肽,有促智和提高认知作用。
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Omberacetam (Noopept) 是一种可作为膳食补充剂的合成二肽,有促智和提高认知作用。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 198 | 现货 | |
5 mg | ¥ 328 | 现货 | |
10 mg | ¥ 528 | 现货 | |
25 mg | ¥ 1,060 | 现货 | |
50 mg | ¥ 1,730 | 现货 | |
100 mg | ¥ 2,660 | 现货 | |
200 mg | ¥ 3,890 | 现货 | |
500 mg | ¥ 6,170 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 363 | 现货 |
产品描述 | Omberacetam (Noopept) is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other related racetam compounds. |
体外活性 | Omberacetam(以10 μM浓度加入培养基,于Аβ 25-35前72小时)对Аβ 25-35(5 μM,24小时)诱导的PC12细胞损伤的神经保护作用进行了研究。考察了化合物对由Аβ 25-35引起的细胞活性、钙稳态、ROS水平、线粒体功能、tau蛋白磷酸化以及神经突起生长损伤的保护能力。PC12细胞暴露于Аβ 25-35后,观察到ROS水平、细胞内钙和Ser396处tau蛋白磷酸化水平的增加;这些改变伴随着细胞活性下降和凋亡增加。Omberacetam处理改善了PC12细胞的存活率,降低了早期和晚期凋亡细胞的数量,减少了细胞内活性氧和钙的水平,提高了线粒体膜电位。此外,Omberacetam预处理显著减轻了Аβ25-35引起的tau蛋白在Ser396处的过度磷酸化,并改善了神经突起生长的变化。 |
体内活性 | Noopept在长期(21天)治疗后通过提高受训动物的百分比[2],消除了学习性无助的表现。 |
细胞实验 | PC12 cells were cultured routinely at 37°C in DMEM medium, supplemented with 10% fetal bovine serum (FBS), 5% horse serum, 2 mM L-glutamine, 50 μg/ml gentamicin. To induce PC12 differentiation, NGF (50 ng/ml) was added to the DMEM containing 1% FBS, followed by a 5-day incubation. Differentiated PC12 (dPC12) cells were pretreated with noopept at concentration of 10 μM for 72 h, then cells were rinsed with the medium and exposed to amyloid-β-peptide (Аβ25–35;5 μM) for 24 h. Untreated cells were used as control[1]. |
动物实验 | Experiments were carried out on adult outbred albino male rats (n=376; 250-300 g) kept under vivarium conditions with 12-h light period with free access to water and standard food. The operant training was performed in a modified setup for active avoidance conditioning under conditions of uncertain environment.The animals were intraperitoneally injected (1 ml/kg) with noopept (0.1, 0.5, and 1.0 mg/kg) and piracetam (100, 300, and 500 mg/kg; reference drug), afobazol (1, 5, and 10 mg/kg), and buspiron (0.5, 1.0, and 5.0 mg/kg; reference drug) and diazepam (0.05, 0.1, and 0.5 mg/kg; reference drug). Control rats were injected with the same volume of saline. Stability of active avoidance behavior was tested after 48 h and 7 days. The animals with learned helplessness neurosis were injected with noopept and afobazol for 21 days, after which stability of the active avoidance behavior was repeatedly tested[2]. |
别名 | SGS-111, Noopept, GVS-111 |
分子量 | 318.37 |
分子式 | C17H22N2O4 |
CAS No. | 157115-85-0 |
Smiles | CCOC(=O)CNC(=O)C1CCCN1C(=O)CC1=CC=CC=C1 |
密度 | 1.202g/cm3 |
存储 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 100 mg/mL (314.10 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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