Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Levcromakalim (BRL 38227) 是 一种 ATP 敏感性的 K+通道 (KATP) 激活剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 438 | 现货 | ||
2 mg | ¥ 632 | 现货 | ||
5 mg | ¥ 858 | 现货 | ||
10 mg | ¥ 1,290 | 现货 | ||
25 mg | ¥ 2,970 | 现货 | ||
50 mg | ¥ 4,380 | 现货 | ||
100 mg | ¥ 6,230 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 945 | 现货 |
产品描述 | Levcromakalim (BRL 38227) is an activator of the ATP-sensitive K+ channel. |
体外活性 | Levcromakalim inhibits spontaneous contractions completely in a glibenclamide-sensitive manner. LevCromakalim (5 μM) inhibits spontaneous contractions, which are recovered by glibenclamide. Levcromakalim (1, 5 and 10 μM) inhibits phasic contractions to 34±21.1%, 20.1±20.0% and 0% of the control. Glibenclamide reverses the inhibition of spontaneous isometric contractions caused by LevCromakalim (5 μM) to 84±1.5% of the control. Levcromakalim (20 and 100 μM) also inhibits oxytocin (OXT) (10 nM)-induced phasic contractions to 34±21.4% and 14±12.6% of the control [2]. LevCromakalim induces dose-dependent relaxation in both the young and old mesenteric artery (MAs); there is no difference in relaxation with age. However, the relaxation is markedly reduced in response to the high-salt (HS) diet in the old MAs (P<0.05). Maximum dilations to Levcromakalim (10-4 M) are 97 ± 3% in the young MAs versus 98 ± 1% in the young salt arteries, while dilations are 99±0.7% in the old MAs when compared with 85 ± 5% in the old salt arteries (P<0.05) [3]. |
别名 | (-)-Cromakalim, 左色满卡林, BRL 38227 |
分子量 | 286.33 |
分子式 | C16H18N2O3 |
CAS No. | 94535-50-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 50 mg/mL (174.62 mM )
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4925 mL | 17.4624 mL | 34.9247 mL | 87.3118 mL |
5 mM | 0.6985 mL | 3.4925 mL | 6.9849 mL | 17.4624 mL | |
10 mM | 0.3492 mL | 1.7462 mL | 3.4925 mL | 8.7312 mL | |
20 mM | 0.1746 mL | 0.8731 mL | 1.7462 mL | 4.3656 mL | |
50 mM | 0.0698 mL | 0.3492 mL | 0.6985 mL | 1.7462 mL | |
100 mM | 0.0349 mL | 0.1746 mL | 0.3492 mL | 0.8731 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Levcromakalim 94535-50-9 Membrane transporter/Ion channel Potassium Channel KcsA BRL38227 Inhibitor (-)-Cromakalim inhibit 左色满卡林 BRL-38227 BRL 38227 Cromakalim inhibitor