CP-547632 hydrochloride

Name: CP-547632 hydrochloride
Brand: TargetMol
SKU: T10870
Price: 227 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T10870Cas号 252003-71-7

CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficacy.

CP-547632 hydrochloride

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产品编号 T10870Cas号 252003-71-7

CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficacy.

规格	价格	库存
2 mg	¥ 468	5日内发货
5 mg	¥ 858	5日内发货
100 mg	¥ 7,960	5日内发货

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产品介绍

生物活性

产品描述	CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficacy.
靶点活性	VEGFR2:11 nM, FGFR:9 nM
体外活性	CP-547632 hydrochloride (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion (IC50: 6 nM).
体内活性	In DLD-1, Colo-205, and MDA-MB-231 xenografts, CP-547632 hydrochloride (p.o.; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth. CP-547632 hydrochloride (oral; 50 mg/kg) yields plasma concentrations above 500 ng/ml for 12 hours.

化学信息

分子量	568.86
分子式	C₂₀H₂₅BrClF₂N₅O₃S
CAS No.	252003-71-7

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 38.33 mg/mL (67.38 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7579 mL	8.7895 mL	17.5790 mL	87.8951 mL
5 mM	0.3516 mL	1.7579 mL	3.5158 mL	17.5790 mL
10 mM	0.1758 mL	0.8790 mL	1.7579 mL	8.7895 mL
20 mM	0.0879 mL	0.4395 mL	0.8790 mL	4.3948 mL
50 mM	0.0352 mL	0.1758 mL	0.3516 mL	1.7579 mL