Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S-(+)-Ketoprofen ((S)-(+)-Ketoprofen) 抑制 COX-1和 COX-2的IC50值分别为 1.9 和 27 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 289 | 现货 | ||
100 mg | ¥ 413 | 现货 | ||
200 mg | ¥ 583 | 现货 | ||
500 mg | ¥ 963 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 158 | 现货 |
产品描述 | S-(+)-Ketoprofen ((S)-(+)-Ketoprofen) works by blocking the action of a substance in the body called cyclo-oxygenase. It belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). Cyclo-oxygenase is involved in the production of chemicals in the body called prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause swelling, inflammation and pain. By blocking cyclo-oxygenase, S-(+)-Ketoprofen prevents the production of prostaglandins and therefore reduces inflammation and pain. Along with Peripheral analgesic action it possesses central analgesic action.S-(+)-Ketoprofen is a non-steroidal anti-inflammatory drug. It is manufactured by Menarini, under the tradename Keral. It is available in the UK, as S-(+)-Ketoprofen trometamol, as a prescription-only drug and in Latin America as Miracox, produced by Stein in Costa Rica. In Italy it is available as an over the counter-drug under the tradename Enantyum. In Lithuania it is available as over the counter-drug uder tradename Dolmen. |
靶点活性 | COX-2:27 nM, COX-1:1.9 nM |
别名 | RP-19583, Dexketoprofen, (S)-(+)-Ketoprofen, (S)-Ketoprofen, (S)-(+)-酮洛芬, 右旋酮洛芬 |
分子量 | 254.28 |
分子式 | C16H14O3 |
CAS No. | 22161-81-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (491.58 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.9327 mL | 19.6634 mL | 39.3267 mL | 98.3168 mL |
5 mM | 0.7865 mL | 3.9327 mL | 7.8653 mL | 19.6634 mL | |
10 mM | 0.3933 mL | 1.9663 mL | 3.9327 mL | 9.8317 mL | |
20 mM | 0.1966 mL | 0.9832 mL | 1.9663 mL | 4.9158 mL | |
50 mM | 0.0787 mL | 0.3933 mL | 0.7865 mL | 1.9663 mL | |
100 mM | 0.0393 mL | 0.1966 mL | 0.3933 mL | 0.9832 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
S-(+)-Ketoprofen 22161-81-5 Immunology/Inflammation Neuroscience COX RP-19583 Dexketoprofen Ketoprofen RP 19583 (S)-(+)-Ketoprofen S-Ketoprofen Inhibitor (S)-Ketoprofen S(+)Ketoprofen (S)-(+)-酮洛芬 S (+) Ketoprofen inhibit RP19583 Cyclooxygenase 右旋酮洛芬 inhibitor