Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. Fenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation.

ATP systhesis:0.88 μM(Ki)

Fenbufen and its metabolites could be involved in mitochondrial toxicity through inhibition of ATP synthesis[1]. Fenbufen inhibited prostaglandin release by 80% and reduced rates of protein synthesis in normal muscle and in muscle undergoing hypertrophy in response to tenotomy of a synergist[3].