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Search Results for " ankylosing spondylitis "

Targets Recommended: COX

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1432	Phenylbutazone Butazolidine,保泰松	COX	Immunology/Inflammation; Neuroscience
	Phenylbutazone (Butazolidine) 是是非甾体类抗炎药，前列腺素 H 合酶过氧化物酶的还原辅助因子，可诱导肌肉盲样蛋白 1 表达，有用于强直性脊柱炎的研究潜力。
T1421	Aceclofenac 醋氯芬酸,Preservex,Airtal	COX	Immunology/Inflammation; Neuroscience
	Aceclofenac (Preservex) 是一种可口服的非甾体抗炎药，可用于缓解疼痛、骨关节炎、强直性脊柱炎、类风湿性关节炎的研究。
T6668	SGC-CBP30	Epigenetic Reader Domain; Histone Acetyltransferase	Chromatin/Epigenetic
	SGC-CBP30 是高选择性CBP/p300溴结构域的有效抑制剂，对CBP 和p300的Kd 值分别为 21 和 32 nM。它强烈减少 Th17 细胞中 IL-17A 的分泌，具有抗炎作用。
T0859	Fenbufen 芬布芬,CL-82204,Lederfen	ATPase; Caspase; COX	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Proteases/Proteasome
	Fenbufen (Lederfen) 是一种非甾体抗炎药，主要用于治疗骨关节炎、强直性脊柱炎和肌腱炎的炎症。它还可用于缓解背痛、扭伤和骨折，具有 caspases 的抑制活性。它对 COX-1和 COX-2具有抑制活性，其 IC50分别为 3.9 μM 和 8.1 μM。
T9901	Adalimumab	TNF	Apoptosis
	Adalimumab 是一种特异性靶向人 TNF-α 的全人重组 IgG1 单克隆抗体。Adalimumab 可以用于治疗类风湿关节炎、强直性脊柱炎、银屑病等。
T26710	Azapropazone DuP-141,NSC-102824,AHR-3018,AHR 3018,MI-85	Others	Others
	Azapropazone is anti-inflammatory agent. Azapropazone has uricosuric properties used to treat rheumatoid arthritis and ankylosing spondylitis. Azapropazone lowered plasma uric acid but exerted only a modest and variable uricosuric effect without altering
T36525	IL-17 modulator 1 disodium	Others	Others
	IL-17 Modulator 1 (disodium) is a potent, orally active compound, known for its high efficacy in modulating IL-17. This compound is extensively utilized for researching various diseases such as psoriasis, ankylosing spondylitis, and psoriatic arthritis[1].
T40106	IL-17 modulator 1
	IL-17 modulator 1 is an orally active small molecule. It is highly efficacious in modulating IL-17 and can effectively prevent, treat, or ameliorate various diseases such as psoriasis, ankylosing spondylitis, and psoriatic arthritis.
T77098	Netakimab
	Netakimab为抗IL-17单克隆抗体。Nerelimomab适用于研究强直性脊柱炎、银屑病关节炎及中重度斑块状银屑病。
T77030	Gumokimab
	Gumokimab (AK 111) 是靶向IL-17A 的单克隆抗体，可用于银屑病、强直性脊柱炎的研究。Gumokimab 能够竞争性阻断人IL-17A 与IL-17R 的结合。
T72653	(R)-Elsubrutinib (R)-ABBV-105	Others	Others
	(R)-Elsubrutinib ((R)-ABBV-105) 是一种Btk 抑制剂。(R)-Elsubrutinib 可用于免疫性疾病 (如类风湿性关节炎、银屑病、强直性脊柱炎、哮喘和系统性红斑狼疮) 和癌症的研究。

化合物

Phenylbutazone

Cat.No: T1432

Synonym: Butazolidine,保泰松

Target: COX

Aceclofenac

Cat.No: T1421

Synonym: 醋氯芬酸,Preservex,Airtal

Target: Epigenetic Reader Domain, Histone Acetyltransferase

Fenbufen

Cat.No: T0859

Synonym: 芬布芬,CL-82204,Lederfen

Target: ATPase, Caspase, COX

Synonym: DuP-141,NSC-102824,AHR-3018,AHR 3018,MI-85

Target: Others

IL-17 modulator 1 disodium

Synonym: (R)-ABBV-105

Target: Others

Species：

Expression System：

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Cat. No.	Product Name	Species	Expression System
TMPJ-01312	TWEAKR/TNFRSF12A Protein, Mouse, Recombinant (hFc) Fibroblast growth factor-regulated protein 2,TNFRSF12,Tumor ...	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 12A(Tnfrsf12a) is a single-pass type I membrane protein and contains 1 TNFR-Cys repeat. It is weak inducer of apoptosis in some cell types.It promotes angiogenesis and it is the proliferation of endothelial cells. It may modulate cellular adhesion to matrix proteins.TNFR binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors. TNF is a naturally occurring cytokine that is involved in normal inf...

重组蛋白

TWEAKR/TNFRSF12A Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01312

Species: Mouse

Expression System: HEK293 Cells

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