Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(RS)-(Tetrazol-5-yl)glycine (LY 285265) 是一种高效且选择性的 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂。它能够诱导小鼠癫痫发作反应和 Fos。它对 GluN1/GluN2D 和 GluN1/GluN2A 的EC50分别为 99 nM,1.7 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 247 | 现货 | ||
5 mg | ¥ 628 | 现货 | ||
10 mg | ¥ 1,080 | 现货 | ||
25 mg | ¥ 2,390 | 现货 | ||
50 mg | ¥ 3,630 | 现货 | ||
100 mg | ¥ 5,250 | 现货 | ||
500 mg | ¥ 10,800 | 现货 |
产品描述 | (RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D, and GluN1/GluN2A, respectively. |
靶点活性 | GluN1/GluN2D:(EC50)99 nM, GluN1/GluN2A:1.7 μM(EC50) |
体外活性 | (RS)-(Tetrazol-5-yl)glycine does not appreciably inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM). (RS)-(Tetrazol-5-yl)glycine displaces NMDA receptor binding to rat brain membranes as measured using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands [1]. |
体内活性 | (RS)-(Tetrazol-5-yl)glycine is a potent convulsant when given to neonatal rats (ED50=0.071 mg/kg; i.p.). (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine; 1.25, 1.5 mg/kg; IP) causes seizure responses and Fos in the NR1+/+ and NR1-/- mice [1][3]. |
别名 | LY 285265, D,L-(tetrazol-5-yl)glycine |
分子量 | 143.1 |
分子式 | C3H5N5O2 |
CAS No. | 138199-51-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 1.43 mg/mL (10 mM, insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 6.9881 mL | 34.9406 mL | 69.8812 mL | 174.703 mL |
5 mM | 1.3976 mL | 6.9881 mL | 13.9762 mL | 34.9406 mL | |
10 mM | 0.6988 mL | 3.4941 mL | 6.9881 mL | 17.4703 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(RS)-(Tetrazol-5-yl)glycine 138199-51-6 Membrane transporter/Ion channel Neuroscience NMDAR iGluR LY285265 Fos GluN2D Ionotropic glutamate receptors inhibit LY-285265 Inhibitor (RS)(Tetrazol5yl)glycine GluN1 (RS) (Tetrazol 5 yl)glycine LY 285265 D,L-(tetrazol-5-yl)glycine GluN2A NMDA seizure inhibitor