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TPN171是一种有效的 PDE5抑制剂,对 PDE5具有亚纳摩尔效价,对 PDE5比对 PDE6具有良好的选择性,具有治疗肺动脉高压(PAH)的潜力。在动物模型中,TPN171被证明具有比西地那非更持久的作用,为临床使用每日一次口服提供了基础。
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TPN171是一种有效的 PDE5抑制剂,对 PDE5具有亚纳摩尔效价,对 PDE5比对 PDE6具有良好的选择性,具有治疗肺动脉高压(PAH)的潜力。在动物模型中,TPN171被证明具有比西地那非更持久的作用,为临床使用每日一次口服提供了基础。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,080 | 现货 | |
5 mg | ¥ 2,690 | 现货 | |
10 mg | ¥ 3,830 | 现货 | |
25 mg | ¥ 5,790 | 现货 | |
50 mg | ¥ 7,680 | 现货 | |
100 mg | ¥ 10,500 | 现货 | |
500 mg | ¥ 19,800 | 现货 |
产品描述 | TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH). TPN171 was proven to exert a longer lasting effect than sildenafil in animal models, providing a foundation for a once-daily oral administration for its clinical use. |
靶点活性 | PDE5:0.62 nM |
分子量 | 441.57 |
分子式 | C24H35N5O3 |
CAS No. | 1229018-87-4 |
Smiles | CCCOc1ccc(NC(=O)CN2CCN(C)CC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1 |
密度 | 1.20 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 4.42 mg/mL (10 mM), Sonication is recommended. | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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