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RG7713 (RO 5028442) 是一种高效且有选择性的脑-渗透加压素 1a (V1a) 受体拮抗剂,对人类 (hV1a) 和小鼠 (mV1a) 受体的 Ki 值分别为 1 和 39 nM,可用于研究自闭症的试验。
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RG7713 (RO 5028442) 是一种高效且有选择性的脑-渗透加压素 1a (V1a) 受体拮抗剂,对人类 (hV1a) 和小鼠 (mV1a) 受体的 Ki 值分别为 1 和 39 nM,可用于研究自闭症的试验。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 997 | 现货 | |
5 mg | ¥ 2,660 | 现货 | |
10 mg | ¥ 4,220 | 现货 | |
25 mg | ¥ 6,750 | 现货 | |
50 mg | ¥ 9,150 | 现货 | |
100 mg | ¥ 12,300 | 现货 |
产品描述 | RG7713 (RO 5028442) has been used in trials studying Autistic Disorder. |
靶点活性 | V1a receptor (human):1 nM(Ki), V1a receptor (mouse):39nM(Ki) |
体外活性 | RO5028442 (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RO5028442 shows high solubility. RO5028442 is found to be highly selective against a panel of 89 targets. Finally, RO5028442 is identified as a suitable compound for clinical studies[1]. |
别名 | RO 5028442 |
分子量 | 437.96 |
分子式 | C25H28ClN3O2 |
CAS No. | 920022-47-5 |
Smiles | CN(C)CCn1cc(C(=O)N2CCC3(CC2)OCc2ccccc32)c2ccc(Cl)cc12 |
密度 | 1.28 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 4.38 mg/mL (10 mM), Sonication is recommended. | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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