Abeprazan

Name: Abeprazan
Brand: TargetMol
SKU: T10221L
Price: 973 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T10221LCas号 1902954-60-2

别名 DWP14012

Abeprazan (DWP14012) is a potassium-competitive acid blocker and it is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1]. Abeprazan inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required.

Abeprazan

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产品编号 T10221L 别名 DWP14012Cas号 1902954-60-2

规格	价格	库存
1 mg	¥ 1,610	5日内发货
5 mg	¥ 3,960	5日内发货
10 mg	¥ 6,750	5日内发货
25 mg	¥ 9,700	5日内发货
50 mg	¥ 13,800	5日内发货
100 mg	¥ 17,500	5日内发货
1 mL x 10 mM (in DMSO)	¥ 4,450	5日内发货

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产品介绍

生物活性

产品描述	Abeprazan (DWP14012) is a potassium-competitive acid blocker and it is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1]. Abeprazan inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required.
体外活性	The mechanism of action of Abeprazan is reversibly binding to H+, K+‐ATPase. It unlike that of PPIs, does not require acidic environment for drug activation[1].
体内活性	In various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models[1], DWP14012 inhibited acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion was equal to or greater than that of vonoprazan, a previously approved P-CAB.
别名	DWP14012