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S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) 是口服选择性雄激素受体调节剂(Ki:1.7 nM)。它能够诱导 CV-1 细胞雄激素受体介导的转录激活,提高去势大鼠前列腺、精囊和肛提肌重量。
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S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) 是口服选择性雄激素受体调节剂(Ki:1.7 nM)。它能够诱导 CV-1 细胞雄激素受体介导的转录激活,提高去势大鼠前列腺、精囊和肛提肌重量。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 185 | 现货 | |
5 mg | ¥ 398 | 现货 | |
10 mg | ¥ 663 | 现货 | |
25 mg | ¥ 1,330 | 现货 | |
50 mg | ¥ 1,980 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 448 | 现货 |
产品描述 | S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats. |
靶点活性 | Androgen receptor:1.7 nM(Ki) |
体外活性 | 向CV-1细胞施用10 nM的S-23可诱导AR介导的转录激活[2]。 |
体内活性 | 向去势动物投给S-23可剂量依赖性地增加雄激素依赖性器官的重量。S-23在前列腺和提肛肌中的ED50分别为0.43和0.079毫克/日[2]。 |
别名 | S23, (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide |
分子量 | 416.75 |
分子式 | C18H13ClF4N2O3 |
CAS No. | 1010396-29-8 |
Smiles | C[C@](O)(COc1ccc(Cl)c(F)c1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F |
密度 | 1.48 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (119.98 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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