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J-147 是一种高效的、具有口服活性的、可透过血脑屏障神经保护剂,可增强认知能力。它抑制单胺氧化酶 B 和多巴胺转运体,EC50分别为 1.88 μM 和 0.649 μM。它有研究阿尔茨海默氏症的潜力。
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J-147 是一种高效的、具有口服活性的、可透过血脑屏障神经保护剂,可增强认知能力。它抑制单胺氧化酶 B 和多巴胺转运体,EC50分别为 1.88 μM 和 0.649 μM。它有研究阿尔茨海默氏症的潜力。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 186 | 现货 | |
2 mg | ¥ 258 | 现货 | |
5 mg | ¥ 413 | 现货 | |
10 mg | ¥ 579 | 现货 | |
25 mg | ¥ 892 | 现货 | |
50 mg | ¥ 1,320 | 现货 | |
100 mg | ¥ 1,990 | 现货 | |
500 mg | ¥ 4,780 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 455 | 现货 |
产品描述 | J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neuropathy. |
靶点活性 | Neuroprotection:60-115 nM(EC50) |
别名 | J147 |
分子量 | 350.33 |
分子式 | C18H17F3N2O2 |
CAS No. | 1146963-51-0 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 45 mg/mL (128.45 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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