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S 2101 is an inhibitor of lysine-specific demethylase 1 (LSD1)(IC50 of 0.99 μM, Ki of 0.61 μM and Kinact/Ki of 4560 M/s).
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S 2101 is an inhibitor of lysine-specific demethylase 1 (LSD1)(IC50 of 0.99 μM, Ki of 0.61 μM and Kinact/Ki of 4560 M/s).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 1,180 | 5日内发货 | |
5 mg | ¥ 1,990 | 5日内发货 | |
25 mg | ¥ 6,910 | 6-8周 | |
50 mg | ¥ 9,170 | 6-8周 | |
100 mg | ¥ 14,200 | 6-8周 |
产品描述 | S 2101 is an inhibitor of lysine-specific demethylase 1 (LSD1)(IC50 of 0.99 μM, Ki of 0.61 μM and Kinact/Ki of 4560 M/s). |
靶点活性 | LSD1:(ki)0.61 μM , LSD1:0.99 μM |
体外活性 | S 2101 is an inhibitor of lysine-specific demethylase 1 (LSD1)(IC50 of 0.99 μM, Ki of 0.61 μM and Kinact/Ki of 4560 M/s). S 2101 also displays much lower inhibition activity toward MAO-B with Ki of 17 μM and Kinact/Ki of 18 M/s and MAO-A (Ki=110 μM, Kinact/Ki=60 M/s). The treatment of HEK293T cells with S 2101 results in a dose-dependent increase in the level of H3K4me2, which must have accumulated by the inactivation of LSD1. During the course of S 2101 treatment, the amounts of histone H3 and LSD1 in the nuclear extracts remain essentially unaffected. Because the treatment with 1 μM S 2101 generates a level of H3K4me2 similar to that elicited by 50 μM 2-PCPA, In human cells, S 2101 is assumed to have approximately 50-fold stronger LSD1 inhibition activity than 2-PCPA . |
别名 | S 2101 |
分子量 | 311.75 |
分子式 | C16H16ClF2NO |
CAS No. | 1239262-36-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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