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MKC9989 是一种羟基芳基醛 (HAA) 的抑制剂,抑制 IRE1α的 IC50值在 0.23 到 44 μM 之间。
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MKC9989 是一种羟基芳基醛 (HAA) 的抑制剂,抑制 IRE1α的 IC50值在 0.23 到 44 μM 之间。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 437 | 现货 | |
5 mg | ¥ 1,390 | 现货 | |
10 mg | ¥ 2,130 | 现货 | |
25 mg | ¥ 3,410 | 现货 | |
50 mg | ¥ 4,610 | 现货 | |
100 mg | ¥ 5,920 | 现货 | |
200 mg | ¥ 7,980 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 1,180 | 现货 |
产品描述 | MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM. |
靶点活性 | IRE1α:0.23 to 44 μM |
体外活性 | MKC9989, significantly stabilizes the RIDD target CD59 mRNA when co-administered with thapsigargin relative to thapsigargin treatment alone and modestly increases levels of CD59 mRNA in non-stressed cells, the latter likely reflects the inhibition of baseline RIDD activity. In contrast to effects on XBP1 splicing, MKC9989 moderately stabilizes CD59 levels when administered 2 hour post treatment with thapsigargin.[1]. |
分子量 | 336.34 |
分子式 | C17H20O7 |
CAS No. | 1338934-20-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 49 mg/mL (145.68 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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