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IMR1 是一种Notch 抑制剂,IC50=26 μM。它能够阻止 Maml1 募集到染色质上的 Notch 三元复合体 (NTC),抑制 Notch 靶基因转录,具有抗肿瘤活性。
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IMR1 是一种Notch 抑制剂,IC50=26 μM。它能够阻止 Maml1 募集到染色质上的 Notch 三元复合体 (NTC),抑制 Notch 靶基因转录,具有抗肿瘤活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 125 | 现货 | |
5 mg | ¥ 273 | 现货 | |
10 mg | ¥ 473 | 现货 | |
25 mg | ¥ 972 | 现货 | |
50 mg | ¥ 1,850 | 现货 | |
100 mg | ¥ 2,730 | 现货 | |
200 mg | ¥ 3,890 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 523 | 现货 |
产品描述 | IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L. |
靶点活性 | Notch:6 μMol/L |
细胞实验 | ChIP assay on the HES1 promoter using the indicated antibodies following treatment of OE33 and 786-0 cells with DAPT (15 μM), IMR-1 (25 μM), or vehicle (DMSO) using GAPDH as loading control. (Only for Reference) |
分子量 | 353.41 |
分子式 | C15H15NO5S2 |
CAS No. | 310456-65-6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 60 mg/mL (169.77 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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