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Fezagepras sodium

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产品编号 T12375Cas号 1254472-97-3
别名 Setogepram sodium salt, PBI-4050 sodium salt

Fezagepras sodium (Setogepram sodium salt) 是口服有效的 GPR40 激动剂及 GPR84 拮抗剂或反向激动剂。Fezagepras sodium 可以减轻肝,肾和胰腺纤维化。Fezagepras sodium 具有抗炎,抗增殖和抗纤维化作用。

Fezagepras sodium

Fezagepras sodium

Rating icon 很棒
纯度: 99.59%
产品编号 T12375 别名 Setogepram sodium salt, PBI-4050 sodium saltCas号 1254472-97-3

Fezagepras sodium (Setogepram sodium salt) 是口服有效的 GPR40 激动剂及 GPR84 拮抗剂或反向激动剂。Fezagepras sodium 可以减轻肝,肾和胰腺纤维化。Fezagepras sodium 具有抗炎,抗增殖和抗纤维化作用。

规格价格库存数量
1 mg
¥ 373
现货
5 mg
¥ 870
现货
10 mg
¥ 1,410
现货
25 mg
¥ 2,350
现货
50 mg
¥ 3,430
现货
100 mg
¥ 4,770
现货
500 mg
¥ 9,540
现货
1 mL x 10 mM (in DMSO)
¥ 954
现货
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产品介绍

生物活性
产品描述
Fezagepras sodium (Setogepram sodium salt) is an orally active GPR40 agonist and is an antagonist or inverse agonist for GPR84, with anti-fibrotic, anti-inflammatory and anti-proliferative actions.
体外活性
PBI-4050 inhibited kidney macrophage infiltration, oxidative stress, and TGF-β-mediated fibrotic signaling pathways, and it also protected against the development of tubulointerstitial fibrosis. To confirm a direct antiinflammatory/antifibrotic effect in the kidney, further studies with a nondiabetic model of EGFR-mediated proximal tubule activation confirmed that PBI-4050 dramatically decreased the development of the associated tubulointerstitial injury and macrophage infiltration[1].
体内活性
eNOS-/- db/db mice were treated with PBI-4050 from 8-20 weeks of age (early treatment) or from 16-24 weeks of age (late treatment). PBI-4050 treatment ameliorated the fasting hyperglycemia and abnormal glucose tolerance tests seen in vehicle-treated mice. In addition, PBI-4050 preserved (early treatment) or restored (late treatment) blood insulin levels and increased autophagy in islets. PBI-4050 treatment led to significant improvements in lifespan in the diabetic mice. Both early and late PBI-4050 treatment protected against progression of DN, as indicated by reduced histological glomerular injury and albuminuria, slow decline of glomerular filtration rate, and loss of podocytes[1].
别名Setogepram sodium salt, PBI-4050 sodium salt
化学信息
分子量228.26
分子式C13H17NaO2
CAS No.1254472-97-3
SmilesCCCCCC1=CC(=CC=C1)CC(=O)[O-].[Na+]
密度1.31g/cm3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
H2O: 90 mg/mL (394.29 mM), Sonication is recommended.
DMSO: 60 mg/mL (262.86 mM), Sonication is recommended.
溶液配制表
DMSO/H2O
1mg5mg10mg50mg
1 mM4.3810 mL21.9048 mL43.8097 mL219.0485 mL
5 mM0.8762 mL4.3810 mL8.7619 mL43.8097 mL
10 mM0.4381 mL2.1905 mL4.3810 mL21.9048 mL
20 mM0.2190 mL1.0952 mL2.1905 mL10.9524 mL
50 mM0.0876 mL0.4381 mL0.8762 mL4.3810 mL
100 mM0.0438 mL0.2190 mL0.4381 mL2.1905 mL

SCI 文献

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

对于不同动物的给药剂量换算,您也可以参考 更多

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