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Navarixin (MK-7123) 是一种可口服的 CXCR1和 CXCR2变构拮抗剂,对猕猴 CXCR1的 Kd 值为 41 nM,对大小鼠和猕猴 CXCR2的 Kd 值分别为 0.20、0.20 和 0.08 nM。
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Navarixin (MK-7123) 是一种可口服的 CXCR1和 CXCR2变构拮抗剂,对猕猴 CXCR1的 Kd 值为 41 nM,对大小鼠和猕猴 CXCR2的 Kd 值分别为 0.20、0.20 和 0.08 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 388 | 现货 | |
5 mg | ¥ 816 | 现货 | |
10 mg | ¥ 1,220 | 现货 | |
25 mg | ¥ 2,190 | 现货 | |
50 mg | ¥ 3,290 | 现货 | |
100 mg | ¥ 4,970 | 现货 | |
500 mg | ¥ 9,870 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 863 | 现货 |
产品描述 | Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia. |
靶点活性 | CXCR2 (rat):0.2 nM (Kd), CXCR1 (cynomolgus):41 nM (Kd), CXCR2 (mouse):0.2 nM (Kd), [125I]-CXCL8-CXCR2:0.97 nM (IC50), CXCR2 (cynomolgus):0.08 nM (Kd), [125I]-CXCL8-CXCR1:43 nM (IC50) |
体外活性 | Navarixin is a potent, allosteric antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly[1]. |
别名 | MK-7123, SCH 527123 |
分子量 | 397.42 |
分子式 | C21H23N3O5 |
CAS No. | 473727-83-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/mL (138.39 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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