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Acyclovir (Aciclovir) 是鸟嘌呤类似物和具有口服活性的抗病毒剂。它对HSV-1(IC50为 0.85 μM),HSV-2(IC50为 0.86 μM) 和水痘带状疱疹病毒有活性。
Acyclovir (Aciclovir) 是鸟嘌呤类似物和具有口服活性的抗病毒剂。它对HSV-1(IC50为 0.85 μM),HSV-2(IC50为 0.86 μM) 和水痘带状疱疹病毒有活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 277 | 现货 | |
50 mg | ¥ 460 | 现货 | |
100 mg | ¥ 739 | 现货 | |
500 mg | ¥ 1,263 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 385 | 现货 |
产品描述 | Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. |
靶点活性 | HSV2:0.86 μM (IC50), HSV1:0.85 μM (IC50) |
体外活性 | Acyclovir 对单纯疱疹病毒分离株的敏感性通过在Vero细胞中进行斑点减少测定来确定。IC50值在B2型Vero细胞中持续比H型低2-3倍。单纯疱疹病毒第2型株比第1型株的敏感性低2-10倍[2]。 |
体内活性 | 口服低剂量的acyclovir可能对在接受OKT3治疗的血清阳性患者中预防HSV感染有效。在OKT3治疗结束后继续使用acyclovir预防治疗2至4周,可能防止延迟感染的发生[3]。 |
激酶实验 | Total AMPK activity is measured using the method of Dagher et al. AMPK activity is quantified in the resuspended pellet as incorporation of?32P from [γ-32P]ATP (10 GBq/mmol) into a synthetic peptide with the specific target sequence for AMPK, the SAMS peptide. Radioactivity is measured using a liquid scintillation counter. Protein content in the solution containing the resupended (NH4)2SO4 pellet is determined using the Bradford method. |
别名 | 阿昔洛韦, Aciclovir, Acycloguanosine |
分子量 | 225.2 |
分子式 | C8H11N5O3 |
CAS No. | 59277-89-3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/mL (244.23 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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