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C1s-IN-1 trihydrochloride (Compound A1) 是 C1s 蛋白酶 (C1s protease) 的特异性抑制剂,Ki 为 5.8 μM。该化合物能够抑制 C1s 对 C2 的裂解,IC50 为 85 μM,并抑制经典途径的激活,其 IC50 为 22 μM。此外,C1s-IN-1 trihydrochloride 也是凝血酶 (thrombin) 的竞争性抑制剂,Ki 为 51.2 μM。
C1s-IN-1 trihydrochloride (Compound A1) 是 C1s 蛋白酶 (C1s protease) 的特异性抑制剂,Ki 为 5.8 μM。该化合物能够抑制 C1s 对 C2 的裂解,IC50 为 85 μM,并抑制经典途径的激活,其 IC50 为 22 μM。此外,C1s-IN-1 trihydrochloride 也是凝血酶 (thrombin) 的竞争性抑制剂,Ki 为 51.2 μM。
产品描述 | C1s-IN-1 trihydrochloride (Compound A1) is a selective inhibitor of C1s protease with a Ki of 5.8 μM. This compound inhibits the cleavage of C2 by C1s with an IC50 of 85 μM and prevents activation of the classical pathway, with an IC50 of 22 μM. Additionally, C1s-IN-1 trihydrochloride acts as a competitive inhibitor of thrombin, exhibiting a Ki of 51.2 μM. |
分子量 | 390.74 |
分子式 | C16H22Cl3N5 |
CAS No. | 1376162-36-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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