Namodenoson (2-Cl-IB-MECA) is an adenosine A3 receptor agonist.

A3 receptor:0.33 nM (Ki)

首次注入Namodenoson后，血压迅速下降至初始水平的约50%。这种低血压状态持续时间短。大约15分钟后，血压开始恢复，并迅速回升至稳定值，这一稳定值显著低于对照组的血压值。在第一次注入后150分钟给予Namodenoson的第二剂量，并未引起任何低血压现象。在第二次注入期间，平均动脉压的轻微增加并不特异性于Namodenoson[1]。

Rats were randomly assigned to two treatment groups of 6 animals, which received either two subsequent intravenous infusions of 200 μg/kg 2-chloro-N^6-(3-iodobenzyl)adenosine-5′-N-methylcarboxamide (2-Cl-IB-MECA) during 15 min or two subsequent infusions of the vehicle during 15 min. 2-Cl-IB-MECA was dissolved in dimethylsulfoxide (DMSO) and diluted with a sodium chloride solution to a final 30% (v/v) DMSO solution (a total volume of 765 μl).?Fresh solutions were prepared prior to each experiment.The effect measurements were started at least 45 min prior to the first drug infusion and lasted until 4.5 h after this infusion.?Heart rate and blood pressure were recorded continuously and serial arterial blood samples were drawn for determination of plasma histamine concentrations.?2 h after the first administration the second dose of 2-Cl-IB-MECA (or vehicle) was administered[1].