Ribocil-C

Name: Ribocil-C
Brand: TargetMol
SKU: T12722L
Rating: 4.5 (1 reviews)

还可以

产品编号 T12722LCas号 1825355-56-3

Ribocil-C is a highly selective bacterial riboflavin riboswitches inhibitor.

还可以

产品编号 T12722LCas号 1825355-56-3

Ribocil-C is a highly selective bacterial riboflavin riboswitches inhibitor.

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产品介绍

生物活性

产品描述	Ribocil-C is a highly selective bacterial riboflavin riboswitches inhibitor.
体外活性	Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth. Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis. Ribocil-C controls expression of de novo riboflavin biosynthesis in Escherichia coli [1][2].
体内活性	Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) show a dose-dependent reduction in the bacterial burden of 1.87 and 3.29 log10[CFU per g spleen] reduction respectively versus shamtreated mice. There is no mortality or gross effects of toxicity observed [2].

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 24.6 mg/mL (58.64 mM)

溶液配制表

DMSO