Fidarestat

Name: Fidarestat
Brand: TargetMol
SKU: T15281
Rating: 4.5 (1 reviews)

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产品编号 T15281Cas号 136087-85-9

别名 SNK 860

Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.

Fidarestat

还可以

产品编号 T15281 别名 SNK 860Cas号 136087-85-9

Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.

规格	价格	库存
1 mg	待估	35日内发货
5 mg	待估	35日内发货
10 mg	待估	35日内发货

大包装 & 定制

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产品介绍

生物活性

产品描述	Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.
靶点活性	AKR1B10 (V301L):1.8 μM, AKR1B10:33 μM, Aldose reductase:26 nM
体内活性	Fidarestat (1 or 4 mg/kg. p.o., daily for 4 weeks) decreases the concentrations of sorbitol and fructose in diabetic rats [2].
别名	SNK 860

化学信息

分子量	279.22
分子式	C₁₂H₁₀FN₃O₄
CAS No.	136087-85-9
密度	1.61 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 250 mg/mL (895.35 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5814 mL	17.9070 mL	35.8141 mL	179.0703 mL
5 mM	0.7163 mL	3.5814 mL	7.1628 mL	35.8141 mL
10 mM	0.3581 mL	1.7907 mL	3.5814 mL	17.9070 mL
20 mM	0.1791 mL	0.8954 mL	1.7907 mL	8.9535 mL
50 mM	0.0716 mL	0.3581 mL	0.7163 mL	3.5814 mL
100 mM	0.0358 mL	0.1791 mL	0.3581 mL	1.7907 mL