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MK3697是OX2受体的一种高效选择性拮抗剂,Ki 值为0.95nM。
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MK3697是OX2受体的一种高效选择性拮抗剂,Ki 值为0.95nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 352 | 现货 | |
2 mg | ¥ 528 | 现货 | |
5 mg | ¥ 995 | 现货 | |
10 mg | ¥ 1,230 | 现货 | |
25 mg | ¥ 2,230 | 现货 | |
50 mg | ¥ 3,730 | 现货 | |
100 mg | ¥ 5,390 | 现货 | |
500 mg | ¥ 10,900 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 997 | 现货 |
产品描述 | MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM). |
靶点活性 | OX2:0.95 nM(ki) |
激酶实验 | Cyclin/CDK kinase assay: Recombinant cyclin/CDK holoenzymes are purified from Sf9 cells engineered to produce baculoviruses that express a specific cyclin or CDK. Cyclin/CDK complexes are typically diluted to a final concentration of 50 μg/mL in a kinase reaction buffer containing 50 mM Tris-HCl (pH 8.0), 10 mM MgCl2, 1 mM DTT, and 0.1 mM sodium orthovanadate. For each kinase reaction, 1 μg of enzyme and 20 μL of a 2-μM substrate solution (a biotinylated peptide derived from histone H1) are mixed and combined with 10 μL of diluted Dinaciclib. The reaction is started by the addition of 50 μL of 2 μM ATP and 0.1 μCi of 33P-ATP. Kinase reactions are incubated for 1 hour at room temperature and are stopped by the addition of 0.1% Triton X-100, 1 mM ATP, 5 mM EDTA, and 5 mg/mL streptavidin-coated SPA beads. SPA beads are captured using a 96-well GF/B filter plate and a Filtermate universal harvester. Beads are washed twice with 2 M NaCl and twice with 2 M NaCl containing 1% phosphoric acid. The signal is then assayed using a TopCount 96-well liquid scintillation counter. |
分子量 | 447.51 |
分子式 | C23H21N5O3S |
CAS No. | 1224846-01-8 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/mL (122.9 mM) | |||||||||||||||||||||||||||||||||||
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DMSO
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