K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and virus infection, K6PC-5 presents a promising compound for research purposes.

K6PC-5（1-10 μM；24小时）在剂量依赖性方式下，提高了正常人表皮角质形成细胞（NHEKs）中的角蛋白和紧密蛋白水平。K6PC-5通过细胞内Ca2+信号传导促进角质形成细胞的分化和增殖。此外，K6PC-5激活p42/44细胞外信号调节激酶和c-Jun末端激酶的磷酸化[1]。K6PC-5（1-10 μM；24小时）促进人成纤维细胞的增殖和胶原蛋白的合成。K6PC-5在人成纤维细胞中引起细胞内Ca2+浓度（[Ca2+]i）的振荡[2]。K6PC-5（10, 25和50 μM；48小时）显着减轻EBOV感染EA.hy926细胞所致的感染。K6PC-5显著降低了感染细胞上清液中的病毒滴度，并以剂量依赖的方式显著减少了VP40的含量[3]。

在本质上老化的无毛小鼠（56周岁）中，1%的K6PC-5被局部应用2周。这种K6PC-5处理显著增加了真皮成纤维细胞的数量和胶原蛋白的产生。因此，真皮厚度也显著增加[2]。