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JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) 是补体C3a 受体噻吩拮抗剂,可抑制 C3aR 介导的炎症,对人 C3a 受体的选择性高于 C5a 受体。
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JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) 是补体C3a 受体噻吩拮抗剂,可抑制 C3aR 介导的炎症,对人 C3a 受体的选择性高于 C5a 受体。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 611 | 现货 | |
5 mg | ¥ 1,530 | 现货 | |
10 mg | ¥ 2,430 | 现货 | |
25 mg | ¥ 3,960 | 现货 | |
50 mg | ¥ 5,770 | 现货 | |
100 mg | ¥ 7,920 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 1,780 | 现货 |
产品描述 | JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor. |
体外活性 | In vitro, thiophene compounds potently inhibited intracellular Ca2+ release in human macrophages without
inhibiting the agonist effects in the same concentration range as the related Complement protein C5a[1]. |
体内活性 | JR14a能减少BR103引起的大鼠爪肿胀中的肥大细胞脱颗粒和巨噬细胞浸润[1]。 |
别名 | 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride |
分子量 | 533.47 |
分子式 | C25H26Cl2N4O3S |
CAS No. | 2411440-41-8 |
Smiles | Cc1cc(sc1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 |
密度 | 1.41 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 90 mg/mL (168.71 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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