L-AP4

L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).

产品编号 T15692Cas号 23052-81-5

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L-AP4

产品编号 T15692别名 L-APB, L-AP 4Cas号 23052-81-5

L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).

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规格	价格	库存
1 mg	¥ 980	35日内发货
5 mg	¥ 1,690	35日内发货
10 mg	¥ 2,900	35日内发货
50 mg	¥ 12,000	35日内发货

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产品介绍

生物活性

产品描述	L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).
靶点活性	mGlu7:249 μM (EC50), mGlu4:0.13 μM (EC50), mGlu8:0.29 μM (EC50), mGlu6:1.0 μM (EC50)
体内活性	L-APB(5 to 30 μg; intrathecal injection) obviously enhances the paw withdrawal threshold in response to the application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. The maximal effect of L-APB appears within 45 min and gradually subsided in 120 min following intrathecal administration. Paw withdrawal threshold in response to the application of von Frey filaments before spinal nerve ligation is 22.6±2.4 g. The mechanical threshold decreases significantly (2.3±0.5 g, P<0.05) within 10 days after nerve ligation and remains stable for at least 8 weeks [2].
别名	L-APB, L-AP 4

化学信息

分子量	183.1
分子式	C₄H₁₀NO₅P
CAS No.	23052-81-5

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: 50 mg/mL (273.07 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	5.4615 mL	27.3075 mL	54.6150 mL	273.0748 mL
5 mM	1.0923 mL	5.4615 mL	10.9230 mL	54.6150 mL
10 mM	0.5461 mL	2.7307 mL	5.4615 mL	27.3075 mL
20 mM	0.2731 mL	1.3654 mL	2.7307 mL	13.6537 mL
50 mM	0.1092 mL	0.5461 mL	1.0923 mL	5.4615 mL
100 mM	0.0546 mL	0.2731 mL	0.5461 mL	2.7307 mL