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BI-2852 是具有纳摩尔亲和力的开关 I/II 口袋(SI/II-口袋)的 KRAS 抑制剂,可抑制 KRAS 突变细胞的下游信号传导和抗增殖作用。
BI-2852 是具有纳摩尔亲和力的开关 I/II 口袋(SI/II-口袋)的 KRAS 抑制剂,可抑制 KRAS 突变细胞的下游信号传导和抗增殖作用。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,170 | 现货 | |
5 mg | ¥ 2,930 | 现货 | |
10 mg | ¥ 4,330 | 现货 | |
25 mg | ¥ 6,920 | 现货 | |
50 mg | ¥ 9,360 | 现货 | |
100 mg | ¥ 12,600 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 3,300 | 现货 |
产品描述 | BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells. |
靶点活性 | KRas (G12C):450 nM, KRas (G12C):750 nM (kd) |
体外活性 | BI-2852在低血清和软琼脂条件下对NCI-H358细胞以剂量依赖的方式显示其抗增殖效果,其EC50分别为6.7 μM和5.8 μM。 |
分子量 | 516.59 |
分子式 | C31H28N6O2 |
CAS No. | 2375482-51-0 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/mL (106.47 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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