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Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) 是基于 Thalidomide 的的cereblon 配体,可用于募集CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。
Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) 是基于 Thalidomide 的的cereblon 配体,可用于募集CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
500 mg | ¥ 108 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 108 | 现货 |
产品描述 | Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTAC. |
别名 | 4 - 羟基沙利度胺, 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione |
分子量 | 274.23 |
分子式 | C13H10N2O5 |
CAS No. | 64567-60-8 |
Smiles | O=C1N(C(=O)C=2C1=CC(O)=CC2)C3C(=O)NC(=O)CC3 |
密度 | 1.611g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 60 mg/mL (218.80 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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