Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ANGIOTENSIN IV TFA(12676-15-2(free base)) 是一种不太有效的血管紧张素 AT1 受体激动剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 393 | 现货 | ||
2 mg | ¥ 579 | 现货 | ||
5 mg | ¥ 827 | 现货 | ||
10 mg | ¥ 1,410 | 现货 | ||
25 mg | ¥ 2,750 | 现货 | ||
50 mg | ¥ 3,970 | 现货 | ||
100 mg | ¥ 5,830 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,490 | 现货 |
产品描述 | ANGIOTENSIN IV TFA is a less effective agonist at the angiotensin AT1 receptor. |
体内活性 | Rats with CCH exhibited higher levels of Aβ42, p-tau and pro-inflammatory cytokines in the brain when compared with controls. Infusion of Ang IV significantly reduced the expression of pro-inflammatory cytokines in the brains of rats with CCH. Meanwhile, the reduction of pro-inflammatory cytokines levels caused by Ang IV was reversed by divalinal-Ang IV. During the treatment, the SBP in rats was not significantly altered[1] |
动物实验 | Eight weeks after bilateral CCA ligation surgery, rats were anaesthetized with 10% chloral hydrate and placed in a stereotactic frame. The scalp was reflected under sterile surgical conditions. A brain-infusion cannula coupled via vinyl tubing to an osmotic pump was implanted into the third cerebral ventricle by surgeons who were blinded to the experimental groups. Osmotic pumps were placed subcutaneously between the scapulae and used to infuse two doses of Ang IV (20 nM, 0.15 μl/h and 100 nM, 0.15 μl/h), divalinal-Ang IV (500 nM, 0.15 μl/h) or aCSF (0.15 μl/h) into the third cerebral ventricle, lasting for six weeks. Following this surgery, the wounds were carefully closed with sutures[1] |
分子量 | 888.92 |
分子式 | C42H55F3N8O10 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (28.12 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.125 mL | 5.6248 mL | 11.2496 mL | 28.124 mL |
5 mM | 0.225 mL | 1.125 mL | 2.2499 mL | 5.6248 mL | |
10 mM | 0.1125 mL | 0.5625 mL | 1.125 mL | 2.8124 mL | |
20 mM | 0.0562 mL | 0.2812 mL | 0.5625 mL | 1.4062 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ANGIOTENSIN IV TFA(12676-15-2(free base)) Endocrinology/Hormones RAAS ANGIOTENSIN IV TFA(12676 15 2(free base)) ANGIOTENSIN IV TFA(12676152(free base)) Inhibitor inhibitor inhibit